中国现代医学杂志2016，Vol.26Issue(5)：42-47,6.DOI:10.3969/j.issn.1005-8982.2016.05.009
血清鳞状细胞癌抗原、组织蛋白酶D和糖类抗原125检测对宫颈鳞癌诊断及预测转移的应用价值
Value of serum SCCAg, Cath-D and CA125 in diagnosis and metastasis-prediction of cervical squamous carcinoma
摘要
Abstract
Objective To evaluate the clinical application value of detecting the serum levels of squamous cell carcinoma antigen (SCCAg), cathepsin-D (Cath-D) and carbohydrate antigen (CA125) in the diagnosis and prediction of the metastasis of squamous carcinoma of the cervix (SCC). Methods Serum levels of SCCAg and Cath-D were tested by ELISA, and CA125 level was detected by chemiluminescent immunoassay. All the cases were collected from Jan. 30, 2009 to Apr. 1, 2012. The experiment group consisted of 60 cases with stageⅠA2-IIA SCC. The control group was divided into two subgroups: cervical intraepithelial neoplasia (CIN) group and chronic cervicitis group with 60 cases in each group. Serum levels of SCCAg, Cath-D and CA125 in the experimental group were detected before operation. Then the relationships of serum SCCAg, Cath-D and CA125 levels with pathological features, metastasis and relapse of SCC were analyzed. Results The preoperative serum levels of SCCAg, Cath-D and CA125 in the experiment group were (1.41±0.26) ng/ml, (19.14±1.52) ng/L and (17.42±0.90) u/ml respectively, which were significantly higher than those in the two control groups ( =0.003, 0.005, 0.000, 0.000, 0.000 and 0.000). The serum levels of SCCAg and Cath-D had different degrees of correlations with clinical stage, gross tumor volume, tumor cell differentiation, depth of interstitial infiltra-tion, vascular tumor embolus, para-uterine metastasis, and pelvic lymph node metastasis of SCC, and the dif-ferences were significant ( <0.05). The change of CA125 level was only related to the depth of interstitial invasion of cervical cancer, and the difference was significant ( =0.007). Based on the ROC analysis, the critical values of SCCAg, Cath-D and CA125 for diagnosis of SCC were 1.03 ng/ml, 13.58 ng/L and 8.16 u/ml;and the critical values for predicting metastasis were 3.21 ng/ml, 21.20 ng/L and 12.45 u/ml; and the area un-der the ROC curve (AUC) was 0.954, 0.905 and 0.718, respectively. Conclusions Detection of SCCAg and Cath-D in serum has high clinical value for diagnosing and staging SCC as well as predicting its recurrence. The combination of SCCAg, Cath-D and C A125 could improve the accuracy of predicting metastasis of SCC.关键词
宫颈鳞癌/鳞状细胞癌抗原/组织蛋白酶D/糖类抗原125/诊断/转移Key words
squamous carcinoma of cervix/squamous cell carcinoma antigen/cathepsin-D/carbohydrate antigen 125/diagnosis/metastasis分类
医药卫生引用本文复制引用
王攀,蒋智钢,郑家深,杨昌伟,陈大勇,王东红..血清鳞状细胞癌抗原、组织蛋白酶D和糖类抗原125检测对宫颈鳞癌诊断及预测转移的应用价值[J].中国现代医学杂志,2016,26(5):42-47,6.基金项目
贵州省科技厅基金 （）
