中国药房2016，Vol.27Issue(7)：882-885,4.DOI:10.6039/j.issn.1001-0408.2016.07.06
复方莪术油乳膏外用对大鼠长期毒性实验研究
Long-term Toxicity Study of Compound Zedoary Turmeric Oil Cream for External Use in Rats
摘要
Abstract
OBJECTIVE:To investigate toxic reaction of Compound zedoary turmeric oil cream in experimental rats with long-term consecutive transdermal administration,and to provide reference for safe use of it in the clinic. METHODS:60 SD rats were randomly divided into blank control (cream matrix) group,Compound zedoary turmeric oil cream intact skin and damaged skin low-dose and high-dose(5%,10%)groups,with 12 rats in each group,half male and half female. All of them were given relevant medicine twice a day. 92 d consecutive medication later,general situation of rats were observed,and body weight,blood routine(WBC,RBC,HGB,LYMPH,etc.)and blood biochemical indicators(AST,ALT,PA,etc.)were all detected;systemati-cal observation of organs,organ coefficient calculation and histopathology examination were carried out. RESULTS:There was no statistical significance in those indicators between Compound zedoary turmeric oil cream groups and blank control group (P>0.05),except hemoglobin decreased in intact skin low-dose group,while hemoglobin decreased,LYMPH and PA increased in dam-aged skin high-dose group(P<0.05). Pathology results showed that Compound zedoary turmeric oil cream had no significant toxici-ty for the main organs. CONCLUSIONS:Compound zedoary turmeric oil cream has no long-term toxicity to experimental rats.关键词
复方莪术油乳膏/长期毒性/大鼠Key words
Compound zedoary turmeric oil cream/Long-term toxicity/Rat分类
医药卫生引用本文复制引用
赵小倩,钱英,胡姗姗,梁轩,张明婧,陈泽慧,田应彪..复方莪术油乳膏外用对大鼠长期毒性实验研究[J].中国药房,2016,27(7):882-885,4.基金项目
贵州省中医药管理局中西药、民族医药科学技术研究资助课题 （）
