中国药房2016，Vol.27Issue(7)：889-891,3.DOI:10.6039/j.issn.1001-0408.2016.07.08
山茱萸多糖对血管性痴呆大鼠学习记忆能力的影响及其机制研究
Effects of Cornus officinalis Polysaccharide on Learning and Memory Ability of Vascular Dementia Rats and Its Mechanism
摘要
Abstract
OBJECTIVE:To study the effects of Cornus officinalis polysaccharide on learning and memory ability of vascular dementia (VD) model rats and its mechanism. METHODS:30 rats were randomly divided into sham operation (normal saline) group,model(normal saline)group and C. officinalis polysaccharide(0.28 g/kg)group. Except sham operation group,VD model was induced in other groups and given relevant medicine intragastrically once a day. After 4 weeks,the frequency of leaping over original platform position,water maze mean escape latencies,platform retention time and average swimming distance were detect-ed,and the mRNA and protein expression of brain-derived neurotrophic factor(BDNF)and apoptosis related gene Bcl-2 in hippo-campal tissue of rats were determined. RESULTS:Compared with sham operation group,learning and memory ability of rats in model group weakened,manifesting as the frequency of leaping over original platform position decreased,water maze mean escape latencies prolonged,platform retention time shortened,average swimming distance extended(P<0.05);mRNA and protein expres-sion of BDNF and Bcl-2 in hippocampus decreased significantly (P<0.05). Compared with model group,learning and memory ability of rats in C. officinalis polysaccharide group increased,manifesting as the frequency of leaping over original platform posi-tion increased,water maze mean escape latencies shortened,platform retention time prolonged,average swimming distance short-ened(P<0.05);mRNA and protein expression of BDNF and Bcl-2 in hippocampus was enhanced significantly(P<0.05). CON-CLUSIONS:C. officinalis polysaccharide can improve the learning and memory ability of VD rats,and its mechanism may be asso-ciated with the expression up-regulation of BDNF and Bcl-2 in hippocampus.关键词
山茱萸多糖/脑源性神经生长因子/凋亡相关基因/血管性痴呆/学习记忆/大鼠Key words
Cornus officinalis polysaccharide/Brain-derived neurotrophic factor/Apoptosis related gene/Vascular dementia/Learning and memory/Rat分类
医药卫生引用本文复制引用
李永格,刘庆春..山茱萸多糖对血管性痴呆大鼠学习记忆能力的影响及其机制研究[J].中国药房,2016,27(7):889-891,3.基金项目
河南省高校重点科研项目（No.15B310009）；南阳市2012年科技发展计划项目 （）
