中国药房2016，Vol.27Issue(7)：946-948,949,4.DOI:10.6039/j.issn.1001-0408.2016.07.25
丙基硫氧嘧啶固体脂质纳米粒的制备与质量评价
Preparation and Quality Evaluation of Propylthiouracil Solid Lipid Nanoparticles
摘要
Abstract
OBJECTIVE:To optimize the formulation and preparation technology of Propylthiouracil(PTU)solid lipid nanopar-ticles(PTU-SLN)and to evaluate the quality of PLN-SLN. METHODS:PTU-SLN was prepared by emulsion ultrasound dispersing method. The formulation of PTU-SLN was optimized by orthogonal design with the entrapment efficacy and particle size as index, using the amount of lipid material,soybean lecithin and poloxamer 188 and ultrasonic time as factors. The quality of prepared nanoparticles was evaluated with particle size,Zeta potential,entrapment efficiency,stability and in vitro drug release rate as in-dex. RESULTS:The optimal formulation and technology was as follows as lipid material 0.6 g,soybean lecithin 1.0 g,poloxamer 188 0.8 g,ultrasonic time 10 min. The obtained PTU-SLN was round and smooth in appearance and distributed evenly in particle size with average particle size of 93.5 nm,Zeta potential of -30.8 mV and average entrapment efficiency of 74.9%. Prepared nanoparticles had no significant change after placing for 15 d at 4 ℃. Accumulative release rate of PTU-SLN was 56.1% at 4 hour in vitro and reached 98.4% at 24 hour. CONCLUSIONS:PTU-SLN is prepared successfully and reasonable in technology,and can reach sustained-release effects.关键词
丙基硫氧嘧啶/固体脂质纳米粒/包封率/体外释放/正交试验Key words
Propylthiouracil/Solid lipid nanoparticicles/Encapsulation efficiency/in vitro release/Orthogonal test分类
医药卫生引用本文复制引用
徐雄波,崔叶妹,宋红娟,卜振军,张青松,唐靖,马宁..丙基硫氧嘧啶固体脂质纳米粒的制备与质量评价[J].中国药房,2016,27(7):946-948,949,4.基金项目
湖南省医药卫生科研计划课题项目 （）
