中国真菌学杂志2016，Vol.11Issue(1)：53-57,5.
以 Hsp90为靶点治疗真菌感染的研究进展和展望
Research progress on targeting Hsp90 for antifungal therapy
摘要
Abstract
A promising new strategy to enhance the efficacy of antifungal drugs and block the evolution of drug resistance is to target the molecular chaperone Hsp90.For systemic infections,however,effective combination therapy regimens may re-quire Hsp90 inhibitors that can select target Hsp90 in the pathogen.In this review,we summarize studies of the impact of Hsp90 on drug resistance of fungal pathogens and regulation of key fungal virulence traits,regulator of Hsp90 function and the client proteins,and discuss the challenges for development of Hsp90 inhibitors to treat fungal infections.关键词
医学真菌/抗真菌药物/真菌耐药性/热休克蛋白Key words
fungus/antifungal agents/drug resistance/heat shock protein 90分类
医药卫生引用本文复制引用
杨苏腾,廖勇,巴根,吕雪莲,杨蓉娅..以 Hsp90为靶点治疗真菌感染的研究进展和展望[J].中国真菌学杂志,2016,11(1):53-57,5.基金项目
国家自然科学基金(81301410) （81301410）
