中国卒中杂志2016，Vol.11Issue(3)：184-190,7.DOI:10.3969/j.issn.1673-5765.2016.03.005
磁共振多层并采扩散峰度成像与传统扩散加权成像识别急性缺血性卒中梗死核心的研究
Comparative Study of Multi-band EPI Diffusion Kurtosis Imaging and Diffusion Weighted Imaging in Identifying Infarct Lesion in Acute Ischemic Stroke
摘要
Abstract
Objective To compare the accuracy of multi-band EPI diffusion kurtosis imaging (m-DKI) with traditional diffusion weighted imaging (DWI) in identifying infarct lesion in acute ischemic stroke patients. Methods The patients with suspected acute ischemic stroke who underwent MR examination (3-8 h after onset) were admitted into this study. The MR results showed these patients had no ischemic penumbra. These patients didn’t receive intravenous thrombolytic therapy or thromboembolectomy. The baseline MR included conventional DWI and m-DKI sequence, the follow-up MR of all the patients were carried out in (7±1) days after onset of stroke. The infarct lesion volume of baseline MRI apparent diffusion coefifcient (ADC) map, mean kurtosis (MK) map and follow-up MRI T1 weighted imaging (T1WI) were measured with Mricron. The lesion volume differences between ADC map and T1WI, and between MK map and T1WI were calculated. Then the percentage of difference in the volume of lesion on T1WI was calculated and compared. Results A total of 19 patients were admitted into this study. The baseline DWI of one patient showed ischemic tissue, though the baseline m-DKI and follow-up T1WI didn’t show infarct lesion. The infarct lesion of one patient was located around basal ganglia, which added dififculty to observe and measure the lesion on MK map. The D-value percentage of the volume of lesions of the left 17 patients between MK map and T1WI was (0.25±0.37), while the D-value percentage between ADC map and T1WI was (0.73±0.72) (t=3.968,P=0.001). The volumes of lesion by MK map was much closer to the real size of T1WI. Conclusion In the identification of the final infarct size in acute ischemic stroke, the volume measurement by baseline m-DKI on acute-phase is more reliable than that of conventional DWI.关键词
卒中/扩散峰度成像/梗死核心Key words
Stroke/Diffusion kurtosis imaging/Infarct core引用本文复制引用
何欢,高培毅..磁共振多层并采扩散峰度成像与传统扩散加权成像识别急性缺血性卒中梗死核心的研究[J].中国卒中杂志,2016,11(3):184-190,7.基金项目
国家自然科学基金急性脑梗死责任斑块的组织学及磁共振成像评估研究中美合作项目（812111546）“十二五”国家科技支撑计划项目 （）
