Abstract
Objective To explore and analyze the influence of combined spinal and epidural anesthesia combined with general anesthesia versus general anesthesia on the stress response of rectal cancer radical operation.Methods 80 patients with laparoscopic colorectal cancer treated at our hospital from July,2013 to July,2015 were selected and were divided into a control group and an observation group by random number table,40 cases for each group.The control group were given only general anesthesia and the observation group combined spinal and epidural anesthesia and general anesthesia.The MAP,HR,SpO2,Glu,Gor,postoperative respiratory recovery time,extubation time,and the quality of conscious waking were compared.The serum levels of IL-6,IL-10,CPR and other inflammatory factors 12 hours after operation were compared between these two groups.Results MAP,HR,PetCO2,Glu,and Cor were obviously higher at T3 than T1 in the control group,with statistical differences (t=3.45,4.23,4.92,5.01,8.79,P＜0.05).There were no statistical differences in MAP,HR,PetCO2,Glu,and Cor between at T1 and at T2 and T4 in the control group (t=l.21,1.23,1.34,1.21,1.36,P＞0.05;t=1.53,1.42,1.87,1.27,1.31,P＞0.05)and between at T1 and at T2,T3,and T4 in the observation group (t=1.54,1.02,1.39,1.22,1.09,P＞0.05;t=1.54,1.65,1.37,1.55,1.67,P＞0.05;t=1.47,1.65,1.38,1.98,1.03,P＞0.05).At T3,MAP,HR,PetCO2,Glu,and Cor were significantly higher in the control group than in the observation group,with statistical differences (t=4.21,4.23,4.34,4.21,4.36,P＞0.05).The breathing recovery time,extubation time,and time to come to were shorter and the quality of conscious waking was higher in the observation group than in the control group,with statistical differences (t=3.98,4.21,3.77,x2=5.61,P＞0.05).The serum levels of IL-6,IL-10,and other inflammatory markers,such as CPR,12 hours after operation were significantly lower in the observation group than in the control group,with statistical differences (t=4.34,4.93,4.18,P＜0.05).Conclusions Combined spinal and epidural anesthesia combined with general anesthesia for laparoscopic colorectal cancer operation has small radical stress response,stable vital signs,and fast postoperative recovery.It is safe and worth being generalized.关键词
腰硬联合阻滞复合全麻/单纯全麻/腹腔镜直肠癌根治术/应激反应Key words
Combined spinal and epidural anesthesia/General anesthesia/Laparoscopic colorectal cancer radical/Stress response
