郑州大学学报（医学版）2016，Vol.51Issue(2)：227-232,233,7.DOI:10.13705/j.issn.1671-6825.2016.02.022
三种促排卵方案对不同年龄子宫内膜异位症患者 IVF-ET妊娠及出生结局的影响
Effect of three down-regulation protocols on outcome of IVF-ET in endo-metriosis patients with different ages
摘要
Abstract
Aim:To investigate the best protocol for different aged patients with endometriosis ( EMs) by comparing the effect of three down-regulation protocols on the outcome of IVF-ET.Methods:A total of 203 cycles with 165 EMs pa-tients undergoing IVF-ET were retrospectively evaluated .The patients were grouped according to their ages and three down-regulation protocols:for patients under 35 years old, there were 51 cycles received long protocol ,61 cycles received pro-longed protocol and 24 cycles received modified super-long protocol;for patients over 35 (including 35) years old, they were also grouped into three protocols (16 cycles,33 cycles and 18 cycles, respectively).The laboratory outcome,clinical outcome and the indicators of live-born babies were statistically analyzed between the groups .Results:For patients under 35 years old:higher cleavage rate (99.3%vs 96.0%,P=0.008) and higher good-quality embryo rate (75.7%vs 67.1%, P=0.021), higher implantation rate(42.2%vs 27.1%,P=0.022), higher clinical pregnancy rate (63.3%vs 37.8%, P=0.011), were observed in prolonged protocol group compared with those of long protocol group .For patients over 35 years old:the transferable embryo rate (93.5% vs 70.4% vs 75.5%,P=0.011), good-quality embryo rate (91.9% vs 55.1%vs 65.5%,P<0.001) and embryo utilization rate (95.1% vs 72.6% vs 79.4%,P=0.002) of modified super-long protocol group were significantly higher than those of long protocol group and prolonged protocol group .Conclusion:For patients with EMs under 35 years old,the long protocol is not very suitable , while the prolonged protocol has a relatively better clinical outcome;and for patients with EMs over 35 years old, the laboratory outcome can be the best if using the modified super-long protocol .关键词
子宫内膜异位症/体外受精-胚胎移植/控制性超促排卵/长方案/超长方案/改良超长方案Key words
endometriosis/in vitro fertilization-embryo transfer/controlled ovarian stimulation/long protocol/pro-longed protocol/modified super-long protocol分类
临床医学引用本文复制引用
宋文妍,王雪改,孙莹璞,金海霞,姚桂东,彭兆锋,石森林,杨洪毅,张向阳..三种促排卵方案对不同年龄子宫内膜异位症患者 IVF-ET妊娠及出生结局的影响[J].郑州大学学报（医学版）,2016,51(2):227-232,233,7.基金项目
郑州市科技局项目340600531813；郑州大学第一附属医院青年基金 （）
