检验医学与临床2016，Vol.13Issue(6)：727-729,3.DOI:10.3969/j.issn.1672-9455.2016.06.003
妊娠期甲状腺激素参考值范围的建立与分析
Establishment and analysis of reference range for thyroid hormones in pregnancy
摘要
Abstract
Objective To set up the normal reference rages of serum thyrotropin(TSH ) ,free triidothyronine (FT3) ,free thyroxine (FT4) in pregnant period .Methods A total of 2 314 pregnant women in the obstetrics depart-ment of the Xi′an Municipal Fourth Hospital from January to August 2013 were randomly selected as the observation group ,including 768 early pregnant women ,784 middle pregnant women and 663 late pregnant women .And 768 non-pregnant women were selected as the control group .TSH ,FT3 and FT4 levels were measured by using the electro-chemiluminescence method .Results The reference ranges in the control group ,early ,middle and late pregnancy groups were 0 .84 - 4 .03 ,0 .37 - 4 .12 ,0 .48 - 4 .43 and 0 .84 - 5 .69 μU /mL for TSH ,3 .51 - 5 .84 ,3 .66 - 5 .93 , 3 .50 - 5 .70 and 2 .53 - 4 .92 for pmol/L FT3 ,12 .44 - 20 .27 ,12 .00 - 19 .53 ,10 .46 - 17 .44 ,8 .64 - 15 .99 pmol/L for FT4 respectively .With the pregnancy progression ,the TSH level was increasing gradually ,while the FT3 and FT4 levels were decreasing gradually .The TSH and FT4 levels had statistically significant differences between the early ,middle and late pregnancy groups with the control group (P< 0 .01) .Serum FT3 level had no statistical differ-ence between the early pregnancy group and the control group (P= 0 .674) ,whereas which had statistical difference between the middle and late pregnancy groups with the control group (P< 0 .01) .The TSH ,FT3 and FT4 levels had statistically significant difference among different pregnant periods (P< 0 .01) .Conclusion The obvious differences exist between different pregnant periods and non-pregnancy .Establishing the reference ranges of thyroid hormones at different pregnant periods among healthy pregnant women in different areas and different laboratories is conducive to the diagnosis and treatment of thyroid diseases .关键词
甲状腺激素/妊娠/参考值范围/电化学发光法Key words
thyroid hormone/pregnancy/reference ranges/electrochemiluminescence引用本文复制引用
俞海珍,李立峰..妊娠期甲状腺激素参考值范围的建立与分析[J].检验医学与临床,2016,13(6):727-729,3.基金项目
国家自然科学基金资助项目（11401469）。 （）
