检验医学与临床2016，Vol.13Issue(6)：757-759,3.DOI:10.3969/j.issn.1672-9455.2016.06.013
帕瑞昔布钠预处理对慢性乙型肝炎肝硬化行脾脏手术患者镇痛与凝血功能影响的研究
Influence of of parecoxib sodium pretreatment on analgesia and coagulation function in patients with chronic hepatitis B cirrhosis undergoing liver spleen operation
陈祥剑 1张雪松 1王利1
作者信息
- 1. 上海市公共卫生临床中心麻醉科 257034
- 折叠
摘要
Abstract
Objective To explore the influence of parecoxib sodium pretreatment on analgesia and coagulation function in the patients with chronic hepatitis B cirrhosis undergoing liver spleen operation .Methods A total of 100 cases of chronic hepatitis B cirrhosis undergoing splenectomy in our hospital from January 2012 to February 2015 were selected and divided into the research group(n= 50) and control group(n= 50) .The research group was given parecoxib sodium 40 mg by intravenous injection at 10 min before anesthesia ,while the control group was intrave-nously injected by normal saline 4 mL at 10 min before anesthesia .Then the pressing pump times during sufentanil self-control vein analgesia ,use amount of sufentanil ,adverse reactions at postoperative 24 h ,and thrombin time(TT ) , prothrombin time(PT ) ,platelet(PLT ) count and fibrinogen(FIB) levels at different postoperative time points were compared between the two group .Results The pressing pump times within postoperative 24 h during sufentanil self-control vein analgesia in the research group was less than that in the control group ,the difference was statistically significant(t= 5 .0 ,P < 0 .001) ;TT ,PT ,PLT count and fibrinogen had no statistical differences between the two groups(P> 0 .05) .Conclusion Parecoxib sodium can decrease the dosage of analgesic drugs in the patients with chronic hepatitis B cirrhosis undergoing spleen operation ,moreover without affecting the coagulant function .关键词
帕瑞昔布钠/乙型肝炎肝硬化/镇痛/凝血Key words
parecoxib sodium/hepatitis B cirrhosis/analgesia/coagulation引用本文复制引用
陈祥剑,张雪松,王利..帕瑞昔布钠预处理对慢性乙型肝炎肝硬化行脾脏手术患者镇痛与凝血功能影响的研究[J].检验医学与临床,2016,13(6):757-759,3.
