检验医学与临床2016，Vol.13Issue(6)：783-785,3.DOI:10.3969/j.issn.1672-9455.2016.06.023
Ig同型转换及寡克隆蛋白条带在免疫固定电泳图谱中的形态特点及其对多发性骨髓瘤患者骨髓移植疗效评价的意义
Morphological characteristics of immunoglobulin isotype switch and oligoclonal protein bands in immune fixation electro-phoresis atlas and its significance to effect of bone marrow implantation in patients with multiple myeloma
黄建玲 1黄木荣 1潘碧燕 1刘绮婷 1周远青 1吕伟标 1李亚红1
作者信息
- 1. 广东省佛山市顺德区第一人民医院检验科528300
- 折叠
摘要
Abstract
Objective To study the morphological characteristic of immunoglobulin(Ig) isotype switch and oli-goclonal protein bands in immune fixation electrophoresis(IFE) atlas and its significance to effect evaluation of bone marrow implantation in patients with multiple myeloma(MM ) .Methods Sixty-four MM patients treated in our hos-pital during 2004 - 2014 were selected .The atlas data of serum protein electrophoresis and IFE in the patients with bone marrow implantation were compared between before and after implantation and performed the statistical analy-sis .Results Among 64 cases of MM ,48 .4% of cases had Ig isotype switch and (or) oligoclonal protein bands .The median time of the first appearance of abnormal protein band (APB ) was 1 .8 months after transplant (0 - 29 months) .The IFE results demonstrated that 71 .0% of cases had IgG kappa isotype switch as first appearance ,IgG lambda accounted for 9 .7% ,IgA kappa for 3 .2% ,IgA lambda for 9 .7% ,IgM kappa for 3 .2% and LC for 3 .2% .Af-ter transplantation ,first appearance of IgG kappa isotype switch was more common .The EFS rates in the patients ap-pearing APB and non-APB were 43% and 0 respectively ,the difference was statistically significant (P = 0 .049) ;the CR rates were 86 .7% and 61 .5% respectively with statistical difference(P= 0 .03) .Until the follow up end ,in the 5-year OS comparison between 31 cases of APB and 33 cases of non-APB ,which were 83% and 57% respectively with-out statistical difference(P= 0 .12) .Conclusion The APB appearance during MM treatment process often prompts higher curative effect and better prognosis .The interpretation and correct cognition of newly appeared APB charac-teristics also affect the correct judgment of the curative effect .关键词
多发性髓瘤/Ig同型转换/寡克隆蛋白条带/M蛋白/免疫固定电泳Key words
multiple myeloma/Igisotype switch/oligoclonal bands/M-protein/immunofixation elec-trophoresis引用本文复制引用
黄建玲,黄木荣,潘碧燕,刘绮婷,周远青,吕伟标,李亚红..Ig同型转换及寡克隆蛋白条带在免疫固定电泳图谱中的形态特点及其对多发性骨髓瘤患者骨髓移植疗效评价的意义[J].检验医学与临床,2016,13(6):783-785,3.
