药学研究2016，Vol.35Issue(3)：125-128,184,5.DOI:10.13506/j.cnki.jpr.2016.03.001
黄皮茎枝的化学成分研究
Chemical constituents from the stems of Clausena lansium
摘要
Abstract
Objective To study the chemical constituents from the stems of Clausena lansium (Lour.)Skeels.Meth-ods The chemical constituents were separated and purified by macroporous resin,MCI gel,silica gel,ODS column chroma-tography,Sephadex LH -20,and preparative HPLC,and their structures were determined by the analysis of ultraviolet spec-trum,mass spectrum,and nuclear magnetic resonance spectroscopy.Results Ten compounds were isolated from the H2 O fractions of 95% ethanol extract of the stems of Clausena lansium,and their structures were identified as β-Adenosine(1), Umbelliferone -7 -α-L -rhamnopyranosyl -(1″-6′)-β-D -glucopyranoside(2),Haploperoside A(3),Umbellifer-one -7 -O -β-D -rhamnopyranosyl -(1″-6′)-β-D -glucopyranoside(4),marmesinin(5),Benzyl -O -β-D -apiofuranosyl -(1″-6′)-β-D -glucopyranoside(6),Benzyl -O -β-D -glucopyranoside(7),3 -(4 -hydroxyphe-nyl)-propanoic acid(8),β-hydroxypropiovanillone (9),trans -p -hydroxycinnamic acid(10).Conclusion Com-pounds 1 ~6,8 ~9 were isolated from the plants of genus Clausena L.Compounds 1 showed some inhibitory effects on LPS-induced NO production in murine microglial BV2 cells (IC50 =4.39 μmoL·L -1 ).关键词
黄皮属/黄皮/腺苷/伞形花内酯/对羟基苯丙酸Key words
Clausena L./Clausena lansium(Lour.)Skeels/Adenosine/Umbelliferone/3 -(4 -hydroxyphenyl)-pro-panoic acid分类
中医学引用本文复制引用
刘洁,李创军,杨敬芝,马洁,张东明..黄皮茎枝的化学成分研究[J].药学研究,2016,35(3):125-128,184,5.基金项目
国家自然科学基金 （）
