药学研究2016，Vol.35Issue(3)：133-135,3.DOI:10.13506/j.cnki.jpr.2016.03.003
顺铂与 DMPIBPA 合用体外抗肿瘤作用研究
Study on anti -tumor activity of combined application of cisplatin and DMPIBPA in vitro
摘要
Abstract
Objective To synthesize Z -2 -(3,5 -dimethoxyphenyl -3 -)4 -isobutoxyphenyl)acrylonitrile (DMPIBPA)and preliminarily study the anti -tumor activities of combined application of DMPIBPA with cisplatin(DDP). Methods DMPIBPA was synthesized with 3,5 -dimethoxybenzoic acid as a starting material and HCT116 and L -02 cells were treated with DDP,DMPIBPA and DDP +DMPIBPA,respectively,and the proliferation inhibitory effects were de-termined by MTT assays.Results In HCT116 cells,inhibition ratio of DMPIBPA(100 μmol·L -1 )was 35.3% ±5.0%, and the inhibition ratio of DDP (250 μmol · L -1 ) was 28.9% ±1.3%.When combined use of DMPIBPA (100μmol·L -1 )with DDP(250 μmol·L -1 ),the inhibition ratio was 65.4% ±2.0% in HCT116 cells but was only 36.2%±0.5% in L -02 cells.The growth inhibition activity of combined application of DMPIBPA and DDP significantly stronger than either one compound in HCT116 cells.Conclusion When combined use of DDP and DMPIBPA,it expressed selective and synergistic inhibition effect on HCT116 cells but had not any effect on L -02 cells.关键词
白藜芦醇衍生物/顺铂/联合用药/抗癌活性/四唑盐比色法Key words
Resveratrol derivatives/DDP/Combined application/Anti -tumor activity/MTT assay分类
药学引用本文复制引用
李佳军,马军,田玉顺..顺铂与 DMPIBPA 合用体外抗肿瘤作用研究[J].药学研究,2016,35(3):133-135,3.基金项目
国家自然科学基金 （）
