药学研究2016，Vol.35Issue(3)：136-138,153,4.DOI:10.13506/j.cnki.jpr.2016.03.004
大鼠在体单向肠灌流法对核黄素肠吸收的研究
Intestine absorption study on riboflavin with rat single pass intestinal perfusion technique
摘要
Abstract
Objective To study the absorption of riboflavin in rat intestine.Methods The absorption of riboflavin in the small intestine (duodenum,jejunum and ileum)of rat was investigated using the gravimetry of the rat single pass intes-tinal perfusion technique.The drug concentration was measured by HPLC to acquire drug Pef and Ka .Results The Pef(× 10 -4 cm·s -1 )in duodenum,jejunum and ileum were 1.002 ±0.630,0.818 ±0.386,0.796 ±0.372.The Ka (×10 -3 s -1 )were 1.114 ±0.625,0.905 ±0.452,0.873 ±0.369.Conclusion The riboflavin could be absorbed in all the intesti-nal segments.The best part of intestine to absorb riboflavin was duodenum.关键词
核黄素/肠吸收/单向灌流法/有效渗透系数Key words
Riboflavin/Intestinal absorption/Single pass intestinal perfusion/Effective permeability分类
药学引用本文复制引用
王丽峰,国大亮,黄富强,李涛..大鼠在体单向肠灌流法对核黄素肠吸收的研究[J].药学研究,2016,35(3):136-138,153,4.基金项目
天津中医药大学教育教学改革研究课题 （）
