药学研究2016，Vol.35Issue(3)：157-160,4.DOI:10.13506/j.cnki.jpr.2016.03.011
姜黄素－汉防己碱共递送抗病毒复方脂质体的构建
Preparation of curcumin -tetrandrine co -delivery antiviral compound recipe liposome
摘要
Abstract
Objective To prepare hyaluronan oligosaccharides(oHA)modified antiviral liposome containing curcumin and tetrandrine,and study its release in vitro and stability.Methods The co -deliver antiviral liposomes was prepared by film dispersion method with particle size and entrapment rate as two important indicators,using particle size analyzer to de-termine the particle size and ultraviolet spectrophotometric method for the determination of entrapment efficiency.Results With Box - Behnken response surface optimization method,the optimal preparation (cholesterol and phospholipid ratio) was 2.5∶1.The best curcumin -tetrandrine proportion was 2.8∶1,and oHA was 1.80%.The particle size was 201.06 nm and entrapment efficiency was 70.94%.Conclusion The preparation method showed that liposomes had good stability,u-niform particle size distribution.It proved that the liposome had good in vitro release activity,good stability and had the po-tential use for antiviral nanocarriers.关键词
姜黄素/汉防己碱/抗病毒/脂质体/共递送Key words
Curcumin/Tetrandrine/Antiviral/Liposomeas/Co -delivery分类
药学引用本文复制引用
孙京芳,吉美芳,徐正行,刘宗亮,赵烽,陈大全..姜黄素－汉防己碱共递送抗病毒复方脂质体的构建[J].药学研究,2016,35(3):157-160,4.基金项目
国家自然科学基金项目（No．81302718、No．81573614）；烟台市科技发展计划项目 （）
