药学研究2016，Vol.35Issue(3)：175-178,4.DOI:10.13506/j.cnki.jpr.2016.03.015
氯吡格雷对不同体重的急性缺血性脑卒中患者的疗效观察
The therapeutic effect of clopidogrel on different weight patients with acute ischemic stroke
丁云龙 1赵艳霞 2刘艳3
作者信息
- 1. 靖江市人民医院，江苏 靖江 214500
- 2. 南京市第一医院，江苏 南京 210000
- 3. 南京市第一医院，江苏 南京 210000
- 折叠
摘要
Abstract
Objective Based on normal body mass index,to study the therapeutic effect of clopidogrel on different weight patients with acute ischemic stroke.Methods A total of 126 normal -weight patients with acute ischemic stroke in department of neurology,Nanjing First Hospital from September 2012 to May 2013 were enrolled and evenly divided by gen-der and median weight into low and high weight groups.Platelet aggregation was detected before and 7 days later after taking standard clopidogrel antiplatelet therapy,and stroke recurrence rate and adverse event occurrence rate was followed -up for one year.Results No significant difference in platelet aggregation before (low weight group was 74.1% ±13.2% and high weight group was 74.7% ±13.6%,P =0.802)while statistical difference 34.4% ±9.8% and 39.1% ±14.4% respec-tively,P =0.034)was found 7 days later after taking standard clopidogrel antiplatelet therapy.Two groups of stroke recur-rence rate and adverse event occurrence rate showed no significant difference in one year′s following up.Conclusion Within the range of normal BMI,patients with a lower body weight would have a better anti -platelet effect after taking clo-pidogrel.But further research was needed to see whether such effect would reduce stroke recurrence or increase adverse e-vents.关键词
缺血性脑卒中/氯吡格雷/体重/血小板聚集率Key words
Acute ischemic stroke/Clopidogrel/Weight/Platelet aggregation rate分类
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丁云龙,赵艳霞,刘艳..氯吡格雷对不同体重的急性缺血性脑卒中患者的疗效观察[J].药学研究,2016,35(3):175-178,4.
