陕西中医2016，Vol.37Issue(4)：506-508,3.DOI:10.3969/j.issn.1000-7369.2016.04.061
丹参对于急性微循环障碍大鼠血管内皮细胞的保护作用
The protective effect of Salvia miltiorrhiza on the acute microcirculation disturbance mice vascular endothelial cells
摘要
Abstract
Objective:Research the protective effect and molecular mechanism of Salvia miltiorrhiza on the a‐cute microcirculation disturbance mice ,which caused by epinephrine hydrochloride and Ice water stimulation .Methods :With hydrochloride adrenaline subcutaneous injection to the mice and ice water swimming stimulation to the mice ,mice a‐cute microcirculation disturbance model can be built by Endogenous and exogenous adrenaline work together .The method of ELISA detected the content of ET‐1 .P‐Selection and VEGF in the serum of mice .Lung tissue was stains with Hema‐toxylin‐eosin to observe the Pathomorphology .Results :Pathomorphology showed that Salvia miltiorrhiza can improve microcirculation disturbance mice and relieve Acute lung injury obviously ,and highly reduce the content of ET‐1、P‐Selec‐tion、VEGF .Conclusion :It has the connection with protecting the endothelial cells that salvia miltiorrhiza can improve the mice acute microcirculation disturbance and reduce lung injury ,which caused by epinephrine hydrochloride and Ice water stimulation .关键词
丹参/微循环障碍/血管内皮素/P-择素/动物 ,实验/大鼠Key words
Salvia miltiorrhiza/Microcirculation disturbance/Endothelin P-Selection/Vascular endothelial growth factor/Experiments Animals/Rats分类
医药卫生引用本文复制引用
陈瑶,王胜娟,李朝玲,李锋..丹参对于急性微循环障碍大鼠血管内皮细胞的保护作用[J].陕西中医,2016,37(4):506-508,3.基金项目
国家自然科学基金项目 （）
