山西医科大学学报2016，Vol.47Issue(3)：211-214,4.DOI:10.13753/j.issn.1007-6611.2016.03.004
体检人群中尿酸与脂肪肝的相关性
Association of uric acid with fatty liver disease in health examination subjects
张娟 1王宏刚 1沈鹏 1王立珍 2黄晓丹 3季国忠 3杨晓钟1
作者信息
- 1. 南京医科大学附属淮安第一医院消化内科，淮安 223300
- 2. 南京医科大学第二附属医院体检中心
- 3. 南京医科大学第二附属医院消化医学中心
- 折叠
摘要
Abstract
Objective To explore the correlation between uric acid and fatty liver disease( FLD) in health examination subjects. Methods A total of 32 428 subjects undergoing health check-up in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were enrolled in this study. Height, weight and blood pressure were measured, and routine blood examina-tion, biochemical examination and abdominal ultrasound were performed. Results The overall prevalence of FLD diagnosed by ultra-sonography was 38. 4%(12 448/32 428) and the prevalence of hyperuricemia was 11. 3%(3 666/32 428). The age, body mass index, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase(ALT), aspartate aminotransferase(AST), γ-glutamyl transferase(GGT), total bilirubin, albu-min, blood urea nitrogen, creatinine and uric acid were significantly higher in FLD group than in non-FLD group. Similarly, these me-tabolism-related indicators in patients with hyperuricemia were higher than that in patients with normal uric acid. In addition, the prev-alence of FLD in hyperuricemia patients was 57. 9%(2 122/3 666), higher than that in patients with normal uric acid (35. 9%, 10 326/28 762). Logistic regression analysis revealed that hyperuricemia was positively associated with FLD(OR=2. 454, 95% CI 2. 288-2. 631, P<0. 05). After adjusting for possible factors associated with FLD, multivariate regression analysis showed that the association between hyperuricemia and FLD was also statistically significant(OR=1. 470,95% CI 1. 345-1. 606,P<0. 05). Con-clusion The results suggest hyperuricemia may be an independent risk factor for FLD.关键词
高尿酸血症/脂肪肝/危险因素Key words
hyperuricemia/fatty liver/risk factor分类
医药卫生引用本文复制引用
张娟,王宏刚,沈鹏,王立珍,黄晓丹,季国忠,杨晓钟..体检人群中尿酸与脂肪肝的相关性[J].山西医科大学学报,2016,47(3):211-214,4.
