山西医科大学学报2016，Vol.47Issue(3)：281-284,4.DOI:10.13753/j.issn.1007-6611.2016.03.019
HPV分型检测在宫颈细胞学阴性妇女宫颈病变诊断中的临床意义
Clinical value of HPV typing in the diagnosis of cervical lesions in women with negative cervical cytology
摘要
Abstract
Objective To explore the clinical value of the human papillomavirus( HPV) typing in the diagnosis of cervical lesions of the women aged 30 years or above without cervical cytology abnormalities. Methods The information of 126 female patients was col-lected, and the female patients aged 30 years or above had no abnormalities in thinprep cytology test(TCT) with HPV16,18,31,33 and 45 positive. The pathological examination was chosen as the diagnostic criteria. The relationship between HPV typing and pathological examination was analyzed. Results Among 126 patients, 10 patients(7. 9%) were detected as CINⅠ, and 18 patients(14. 3%) were detected as CINⅡ/Ⅲ. Among 75 cases of positive HPV16, 15 cases(20. 0%) were detected as CINⅡ/Ⅲ. Among 15 cases of positive HPV18, 1 case(6. 7%) was detected as CINⅡ/Ⅲ. Among 16 cases of positive HPV31 and 27 cases of positive HPV33, 1 case(6. 3%) and 2 cases(7. 4%) were detected as CINⅡ/Ⅲ,respectively. Logistic regression analysis showed that the risk of CINⅡ/Ⅲ lesion infected with HPV16 was four times that of no HPV16 infection(95% CI 1. 094-14. 624,P=0. 026<0. 05). Conclusion The women aged 30 years or above without cervical cytology abnormalities but HPV16,18,31,33 and 45 positive have a certain risk of high-level cervical lesions, especially those patients infected with HPV16. Therefore, the colposcopy detection should be recommended timely.关键词
薄层液基细胞学/HPV分型/阴道镜/宫颈上皮内瘤变/宫颈癌Key words
thinprep cytology test/HPV typing/colposcopy/cervical intraepithelial neoplasia/cervical cancer分类
医药卫生引用本文复制引用
殷艳,韦业平,黄燕,罗凤娥,麦虹,刘俐伶,邓丽..HPV分型检测在宫颈细胞学阴性妇女宫颈病变诊断中的临床意义[J].山西医科大学学报,2016,47(3):281-284,4.基金项目
广西壮族自治区卫生厅自筹经费科研基金资助项目(Z2014049) （Z2014049）
