原子能科学技术2016，Vol.50Issue(2)：349-356,8.DOI:10.7538/yzk.2016.50.02.0349
基于模拟点源测量的多针孔SPECT精确迭代重建
Accurate Iterative Reconstruction in Multi-pinhole SPECT Based on Simulation Point Source Measurement
摘要
Abstract
High resolution single photon emission computed tomography (SPECT ) is a very important technology in clinical and small animal imaging .It has been proved that by modeling the system matrix of SPECT and using the iterative reconstruction algo‐rithm ,the spatial resolution can be improved efficiently .In this research ,a method which combines Monte Carlo simulation and analytical model to calculate accurate sys‐tem matrix was studied based on the small animal SPECT system .After the simulated point source projection data were acquired ,the feature parameters of point spread func‐tion (PSF) were extracted by Gaussian fitting .Using the analytical model and the parameters make calculating the accurate PSF of any position in this system possible .In the reconstruction results of using two different system matrixes ,one only used the ana‐lytical model and the other used the new method .The results validate that the method proposed in this paper improves the spatial resolution of image .Furthermore ,the influ‐ence between different point source arrangements was studied in order to acquire a better arrangement .With respect to the method based on the experiment , this method can accurately realize the modeling of system matrix and improve the spatial resolution of image in a more appropriate w ay .关键词
单光子发射计算机断层成像/图像重建/蒙特卡罗模拟/传输矩阵/图像分辨率Key words
single photon emission computed tomography/image reconstruction/Monte Carlo simulation/system matrix/image resolution分类
医药卫生引用本文复制引用
余建概,王石,吴婧,马天予,刘亚强..基于模拟点源测量的多针孔SPECT精确迭代重建[J].原子能科学技术,2016,50(2):349-356,8.基金项目
国家自然科学基金资助项目（11375069，11275105）；清华大学自主科研项目资助（20131089289）；中国博士后科学基金资助项目 （）
