中国感染控制杂志2016，Vol.15Issue(3)：160-163,4.DOI:10.3969/j.issn.1671-9638.2016.03.004
老年下呼吸道感染患者痰分离真菌种类及药物敏感性
Species and antimicrobial susceptibility of fungi isolated from sputum of elderly patients with lower respiratory tract infection
摘要
Abstract
Objective To investigate the species distribution and antimicrobial susceptibility of fungi isolated from lower respiratory tract(LRT)sputum specimens of elderly patients,and provide evidence for preventing and treating fungal infection.Methods Fungi isolated from LRT specimens of elderly patients in 3 hospitals in Yunna subplateau area between January 2010 and October 2014 were collected,identified and performed antifungal susceptibility tes-ting.Results Of 1 887 fungal isolates,Candida albicans (C.albicans )accounted for 65.18%,Mucor (0.69%), Aspergillus nidulans (0.16%)and other rare strains were isolated;the isolated strains were highly sensitive to nystatin (100.00%),amphotericin B (90.14%),and itraconazole (88.98%);but had higher resistance rates to fluconazole (34.29%)and miconazole (36.62%);five common Candida species were all sensitive to nystatin,but resistance rates of C.albicans and C.glabrata to fluconazole and miconazole were up to 35.94%-40.88%,resistance rate of C.albicans to 5-fluorocytosine was 19.51 %.Conclusion Fungal species and antifungal susceptibility testing results should be considered in antifungal treatment for elderly patients.关键词
亚高原/老年/下呼吸道/真菌/感染/抗药性,微生物/耐药性/合理用药Key words
subplateau/the elderly/lower respiratory tract/fungus/infection/drug resistance,microbial/drug resistance/rational drug use分类
医药卫生引用本文复制引用
瞿良,姜昌丽,罗成富,杨天兰,王勤,朱光旭,李雪梅,李云..老年下呼吸道感染患者痰分离真菌种类及药物敏感性[J].中国感染控制杂志,2016,15(3):160-163,4.基金项目
国家自然科学基金项目（81170316／H2501）；国家自然科学基金项目 （）
