中国感染控制杂志2016，Vol.15Issue(3)：164-167,4.DOI:10.3969/j.issn.1671-9638.2016.03.005
某三级医院2012-2015年血培养病原菌分布及其耐药性
Distribution and antimicrobial resistance of pathogens in blood cultures in a tertiary hospital from 2012 to 2015
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance of major pathogens causing bloodstream infection in a tertiary hospital,so as to guide the clinical rational use of antimicrobial agents.Methods Blood specimens from patients with suspected bloodstream infection in this hospital between January 2012 and January 2015 were cultured,identified and performed antimicrobial susceptibility testing,the major pathogens and antimi-crobial susceptibility testing results were analyzed statistically.Results A total of 1 658 strains of pathogens were isolated from 19 326 blood culture specimens,isolation rate was 8.58%,in which gram-negative bacilli,gram-posi-tive cocci,and fungi accounted for 58.57% (n=971 ),39.38% (n=653),and 2.05% (n=34)respectively,the major gram-negative bacillus,gram-positive coccus,and fungus were Escherichia coli ,coagulase-negative staphylo-cocci (CNS),and Candida albicans respectively.The isolated pathogens mainly distributed in departments of hema-tology,gastroenterology,and cardiovascular surgery.Detection rates of extended-spectrumβ-lactamases (ESBLs)-producing Escherichia coli and Klebsiella pneumoniae were 56.35% and 36.14% respectively,but were highly sen-sitive to cefoperazone/sulbactam and carbapenems (resistance rates <3%).The percentage of methicillin-resistant coagulase-negative staphylococcus (MRCNS ) and methicillin-resistant Staphylococcus aureus (MRSA ) were 78.60% and 32.28%respectively,but were highly sensitive to vancomycin and linezolid(resistance rates < 1 %). Conclusion Escherichia coli and CNS are predominant pathogens causing bloodstream infection in this hospital,antimicro-bial resistance rates are high;regular analysis on distribution and antimicrobial resistance of pathogens causing bloodstream infection is helpful for the prevention and control of infection caused by multidrug-resistant organisms.关键词
血流感染/血培养/病原菌/种类分布/抗药性,微生物/耐药性Key words
bloodstream infection/blood culture/pathogen/species distribution/drug resistance,microbial/drug resistance分类
医药卫生引用本文复制引用
陈斌泽,张媛媛,薛荣利,冯强生,哈小琴,彭俊华..某三级医院2012-2015年血培养病原菌分布及其耐药性[J].中国感染控制杂志,2016,15(3):164-167,4.基金项目
甘肃省省青年科技基金计划项目 （）
