中国临床药理学杂志2016，Vol.32Issue(5)：387-389,3.DOI:10.13699/j.cnki.1001-6821.2016.05.001
帕拉米韦氯化钠注射液治疗无并发症的急性单纯性流行性感冒的临床疗效及安全性评价
Clinical efficacy and safety of peramivir trihydrate sodium chloride injection in the treatment of acute simple uncomplicated influenza
李晓光 1胥婕 1李璐 1梁京津 1邓忠华 1贾莹 1林菲 1张碧莹 1康永峰1
作者信息
- 1. 北京大学 第三医院 感染疾病科，北京100191
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of peramivir trihydrate sodium chloride injection in the treatment of acute simple uncomplicated influenza.Methods Accepting the 60 cases of in-fected patients as subjects.All patients were given a single intravenous infusion of peramivir sodium chloride injection 100 mL/0.3 g.Before treatment, 3 days and 7 days after treatment, all patients were inter-viewed 3 times and the subjects ’ symptoms and adverse events were eva-luated.Results Fever response rate was 100%, alleviate time was (23.40 ±13.43 ) h, other symptoms remission rate was 75% to 93%.Adverse events were given priority to the anomalies of laboratory tests , including elevated triglycerides in 11 cases, elevated alanine aminotrans in 1 case, QTc prolongation in 1 case, most of them returned to normal.No serious adverse events appeared.Conclusion Application of perami-vir sodium chloride injection in the treatment of acute simple uncompli-cated influenza is relatively safe and effective.关键词
帕拉米韦/流行性感冒/安全性/临床疗效Key words
peramivir/influenza/safety/clinical efficacy分类
医药卫生引用本文复制引用
李晓光,胥婕,李璐,梁京津,邓忠华,贾莹,林菲,张碧莹,康永峰..帕拉米韦氯化钠注射液治疗无并发症的急性单纯性流行性感冒的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(5):387-389,3.
