中国临床药理学杂志2016，Vol.32Issue(5)：396-398,405,4.DOI:10.13699/j.cnki.1001-6821.2016.05.004
参麦注射液联合左卡尼汀对慢性肺源性心脏病心肺功能的影响
Influencs on cardio -pulmonary function for chronic pulmonary heart disease treated by levocarnitine combined with Shenmai injection
摘要
Abstract
Objective To evaluate cardio -pulmonary function and serum interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α( TNF-α) levels for chronic pulmonary heart disease treated by levocarnitine combined with Shenmai injection and study its mecha-nism.Methods A total of 110 patients with chronic pulmonary heart disease were randomly divided into treatment group ( n=55 ) and control group(n=55).Patients in two groups were treated by oxygen , relieving cough and asthma , cardio tonic , diuresis and expand blood.Patients in control group were given levocarnitine 3 g for 3 weeks , while patients in treatment group given Shenmai injection 100 mL for 3 weeks on the basis of control group.The cardio-pulmonary function improvement , changes of serum IL-6, IL-8, TNF-αlevels and incidence of adverse drug reactions were observed between the two groups.Results The improve-ment of forced expiratory volume in one second ( FEV1 ) , forced vital ca-pacity ( FVC ) , FEV1/FVC, and pulmonary artery pressure ( PAP ) in treatment group were significantly better than those in control group after treatment ( P <0.01 ).E peak and Ve after treatment in two groups were significantly higher than those before treatment.A peak and Va after treatment in two groups were significantly lower than those before treatment , and the changes in treatment group was more significant ( P <0.05 ).The serum IL-6,IL-8,TNF-αlevels after treatment were significantly lower than before treatment , and the decline in treatment group was more obvious than control group ( P<0.05).Conclusion Levocarnitine combined with Shenmai injection could significantly improve the cardio -pulmonary function for chronic pulmonary heart disease , reduce PAP, serum IL-6,IL-8,TNF-αlevels and suppress the inflammatory reaction.关键词
参麦注射液/左卡尼汀/慢性肺源性心脏病/白细胞介素-6/白细胞介素-8/肿瘤坏死因子-αKey words
Shenmai injection/levocarnitine/chronic pulmonary heart disease/serum interleukin -6/serum interleukin-8/tumor necrosis factor -α分类
医药卫生引用本文复制引用
杨继雷,姚秀叶,谷伟,李彦明,董利平..参麦注射液联合左卡尼汀对慢性肺源性心脏病心肺功能的影响[J].中国临床药理学杂志,2016,32(5):396-398,405,4.基金项目
河北省张家口市科技局2014年度指导性计划基金资助项目 （）
