中国临床药理学杂志2016，Vol.32Issue(5)：402-405,4.DOI:10.13699/j.cnki.1001-6821.2016.05.006
供体因素对肾移植术后早期霉酚酸及其代谢物药代动力学的影响
Influence of donor physiological condition on pharmacokinetics of mycophenolic acid and its metabolite in the early period after renal transplantation
摘要
Abstract
Objective To investigate the influence of the physiological conditions and kidney function of the donors on their recipients ’ myco-phenolic acid ( MPA) and mycophenolic acid glucuronide ( MPAG) levels in the early period after renal transplantation.Methods Forty-two pa-tients receiving mycophenolate mofetil ( MMF) and 23 patients receiving enteric-coated mycophenolate sodium ( EC-MPS) , as well as their do-nors were included in this study.For patients who recieving MMF , MPA and MPAG concentrations were detected by HPLC , then AUCMPA and AUCMPAG were calculated by the limited sampling strategy (LSS) model es-tablished by our lab previously.For the patients receiving EC -MPS, AUCMPA and AUCMPAG were calculated by linear trapezoidal rule.Results Spearman test showed significant correlation between recipients ’ AUCMPAG and the age of donors in MMF group , EC-MPS group and the total cohort (P<0.05).Moreover, AUCMPAG in the recipients of elder group (>55 years old) was significantly higher than that in the younger group (≤55 years old) in both MMF group and the total cohort (P<0.05).In addition, AUCMPAG was siginificantly associated with the urea levels of donors before renal transplanta-tion in MMF group and the total cohort ( P<0.05 ).Patients were divided into tacrolimus ( FK506 ) or cyclosporin A ( CsA) group according to their comedication.AUCMPAG was significantly higher in CsA group than that in FK 506 group ( P<0.01 ).AUCMPAG in the recipients of elder group was significantly higher than that in the younger group ( P<0.05), and AUCMPAG was siginificantly associated with the urea levels of donors in FK 506 group (P<0.05).In CsA group, significant correlation between AUC MPAG and the age of donors was showed (P<0.05).Conclusion Our data suggested that the age and the urea level of donors might play roles in the recipients ’ MPAG exposure in the early period after renal transplantation .关键词
供体因素/肾移植术后早期/霉酚酸/药代动力学Key words
donor factors/early period after renal transplantation/mycophenolic acid/pharmacokinetics分类
临床医学引用本文复制引用
刘思,李嘉丽,刘龙山,周守宁,张桓熙,王长希,黄民..供体因素对肾移植术后早期霉酚酸及其代谢物药代动力学的影响[J].中国临床药理学杂志,2016,32(5):402-405,4.基金项目
“十二五”国家科技重大专项基金资助项目（2012ZX09506001－004）；国家自然科学基金资助项目（81102515，81320108027）；广东省重点实验室建设基金资助项目（2011A060901014）；广东省重大科技专项基金资助项目 （）
