中国临床药理学杂志2016，Vol.32Issue(5)：406-408,3.DOI:10.13699/j.cnki.1001-6821.2016.05.007
丁苯酞治疗高危性短暂性脑缺血发作的临床疗效与安全性
Clinical efficacy and safety of butylphthalide in the treatment of patient with transient ischemic attack
摘要
Abstract
Objective To observe the clinical efficacy and safety of butylphthalide in the treatment of patient with transient ischemic attack.Methods Ninety -one cases with transient ischemic attack were ran-domly divided into control group ( n=45 ) and treatment group ( n=46 ).Patients in the control group were administered of ozagrel sodium 80 mg+0.9%NaCl 150 mL, ivgtt, bid; patients in treatment group adminis-tered of butylphthalide 25 mg, ivgtt, bid, two weeks a cycle.After 2 cycles treatment , the clinical efficacy of the two groups , the levels of serum fibrinogen(FIB) and triglyceride (TG) before and after treatment, the carotid intima-media thickness ( cIMT) and the area of the carotid artery, the area of the soft plaque and the incidence of adverse reactions were compared.Results Total clinical efficacy were 86.96%( 40/46 ) and 66.67%(30/45) respectively with statistical difference (P<0.05).The serum levels of TG and FIB were significantly decreased after treat-ment in both the control and treatment group ( P<0.05 ).The serum le-vels of TG and FIB were significant lower than control group after treat-ment ( P<0.05 ).Carotid artery IMT and plaque area in two groups had no significant changes of the two groups ( P >0.05 ).No significant adverse reaction in two groups occurred , only two patients with medication ncrease in transaminase , after 1 month, the aminotransferase levels recovery to normal.Conclusion Significant clini-cal efficacy and safety was found for butylphthalide in the treatment of transient ischemic attack.关键词
短暂性脑缺血发作/丁苯酞/临床疗效/安全性/血脂Key words
transient ischemic attack/butylphthalide/clinical efficacy/safety/blood lipid分类
临床医学引用本文复制引用
瞿砚舟,吕锦,蓝丽康,顾群..丁苯酞治疗高危性短暂性脑缺血发作的临床疗效与安全性[J].中国临床药理学杂志,2016,32(5):406-408,3.基金项目
浙江省公益性应用技术基金资助项目 （）
