中国临床药理学杂志2016，Vol.32Issue(5)：409-411,3.DOI:10.13699/j.cnki.1001-6821.2016.05.008
缬沙坦联合前列地尔对早期糖尿病肾病的临床研究
Clinical study of valsartan combined with alprostadil in the treatment of patient with early diabetic nephropathy
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of al-sartan combined with alprostadil in the treatment of early diabetic ne-phropathy.Methods Ninety-eight early diabetic nephropathy patients were divided into three groups , 33 patients in group A , 31 patients in group B , and 34 patients in group C.Patients in group A were given al-prostadil 100 μg +0.9%NaCl 250 mL, qd.Patients in group B were given valsartan 80 mg, qd.And patients in group C were givenalprostadil 100 μg +0.9%NaCl 250 mL +valsartan 80 mg, qd.After 1 month treatment, the clinical efficacy and serum blood urea nitrogen ( BUN), serum creatinine(Scr) and urinary albumin excretion rate (UAER) were observed in two groups.Results Total efficacy were75.76%, 70.96%and 94.12% for group A, B and C, without no significant statistical difference( P >0.05 ).The BUN, Scr and UAER were significant de-creased after treatment for all three groups ( P<0.05 ) , group C much lower than other groups after treatment ( P<0.05 ).The incidence rates of adverse drug reactions were 9.09%, 12.90%and 11.76% for the 3 groups , with no statistical difference ( P>0.05 ).Conclusion The clini-cal efficacy of valsartan combined with alprostadil was superior to the sin-gle drug in the treatment of early diabetic nephropathy which could de-creased the BUN , Scr and UAER.关键词
糖尿病肾病/缬沙坦/前列地尔/尿素氮/血清肌酸酐/尿白蛋白排泄率Key words
diabetic nephropathy/valsartan/alprostadil/serumblood urea nitrogen ( BUN )/serum creatinine ( Scr )/urinary albumin excretion rate ( UAER)分类
临床医学引用本文复制引用
马亚丽,陈芳,时军,陈宝平..缬沙坦联合前列地尔对早期糖尿病肾病的临床研究[J].中国临床药理学杂志,2016,32(5):409-411,3.基金项目
河南省卫生厅、河南省医学科技公关计划基金资助项目 （）
