中国临床药理学杂志2016，Vol.32Issue(5)：412-414,3.DOI:10.13699/j.cnki.1001-6821.2016.05.009
氨酚羟考酮用于脊柱手术后镇痛临床疗效及安全性评价
Efficacy and safety of oxycodone hydrochloride for postoperative analgesia in spin surgery patients
摘要
Abstract
Objective To evaluate the efficacy and safety of oxycodone hydrochloride for postoperative analgesia in patients who received spin surgery.Methods Sixty -nine patients treated with spin surgery were included in this study and randomly divided into treatment group ( n=34 ) and control group ( n=35).Half an hour before the end of operation ,the patients of the two group were given oxycodone hydrochloride and morphine 0.07 mg · kg-1 , respectively.After extubation , patient -controlled analgesia pump was given with the background dosage of 0.5 mg · h -1 and one time push 1 mg of oxycodone hydrochloride or morphine.The mean arterial pressure ( MAP) , and heart rate were com-pared in the time points of entering the operation room ( T0 ) ,tracheal in-tubation ( T1 ) , 5 min after tracheal intubation ( T2 ) , and 15 min after tra-cheal intubation(T3) between the two groups.The recovery time, extu-bation time ,visual analogue scale ( VAS) ,observer assessment of sedation ( OAA/S ) score and safety were compared between the two groups . Results The MAP and heart rate were not statistically different between the two groups and among the time points ( P>0.05 ).The recovery time , extubation time , VAS, OAA/S score in treatment group were significant lower than those of control group( P<0.05 ).The adverse drug reaction rates were 17.14%and 8.82% in the control group and treatment group respectively with statistical difference ( P<0.05 ).Conclusion Compared with morphine , oxycodone hydrochloride is more effective and safe for postoperative analgesia in patients who received spin surgery.关键词
脊柱手术/氨酚羟考酮/吗啡/镇痛效果/安全性Key words
spine surgery/oxycodone hydrochloride/morphine/analgesia efficacy/safety分类
临床医学引用本文复制引用
葛云林,卢一生,符楚迪,潘兵..氨酚羟考酮用于脊柱手术后镇痛临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(5):412-414,3.基金项目
解放军医药卫生科研基金资助项目 （）
