中国临床药理学杂志2016，Vol.32Issue(5)：418-420,3.DOI:10.13699/j.cnki.1001-6821.2016.05.011
人参总皂苷对慢性心力衰竭大鼠血流动力学及caspase－3表达的影响
Effect of ginseng total saponins on hemodynamics and caspase -3 expression of myocardial cells in rats with chronic heart failure
摘要
Abstract
Objective To study the effect of Ginseng total saponins ( GS) on hemodynamics and caspase -3 expression of myocardial cells in rats with chronic heart failure.Methods Fifty male Wistar rats were randomly divided into control group , model group , GS low group ( GS-L),GS moderate group(GS-M) and GS high group(GS-H) with each group 10 rats.Rats in control group and model group were given distilled water 40 mL once daily.Rats in the GS groups were given GS 5 , 20 and 80 mg· kg -1 gavage qd for 4 weeks.The changes of blood flow and the concentrations of brain natriuretic peptide (BNP) and Ca2+in myocardi-um in rats were measured.Results Compared with the control group , the model group and GS group were significantly lower in aspects of left ventricular systolic pressure ( LVSP) and the maximum change rate of left ventricular pressure(-dp/dtmax) (P<0.05).But GS group was signifi-cantly higher than the model group ( P<0.05 ).Compared with the con-trol group, the model group and GS group were significantly higher in as-pects of left ventricular end -diastolic pressure (LVEDP) and +dp/dtmax ( P<0.05 ).The GS group was significantly lower than the model group ( P<0.05 ).Compared with control group , brain natriuretic peptide ( BNP) and Ca2+in model group were significantly elevated (P<0.05);GS group was signifi-cantly lower than that of model group ( P<0.05 ).The expression of Caspase -3 in the control and GS groups was sig-nificantly lower than that in the model group ( P<0.05 ) , but the GS group was significantly higher than that in the control group ( P<0.05 ).Conclusion GS can improve the hemodynamic parameters of heart failure rats and decrease the concentration of calcium ion in cardiac muscle cells.The mechanism may be related to the inhibition of Caspase -3 expression in cardiomyocytes.关键词
人参总皂苷/心力衰竭/血流动力学/半胱氨酸天冬氨酸蛋白酶3Key words
Ginseng total saponins/heart failure/hemodynamics caspase -3分类
中医学引用本文复制引用
吴庆..人参总皂苷对慢性心力衰竭大鼠血流动力学及caspase－3表达的影响[J].中国临床药理学杂志,2016,32(5):418-420,3.基金项目
重庆市卫生局科技基金资助项目 （）
