中国临床药理学杂志2016，Vol.32Issue(5)：466-468,3.DOI:10.13699/j.cnki.1001-6821.2016.05.026
阿司匹林和质子泵抑制剂固定复方制剂的立题合理性探讨
Rationality of developing fixed -dose combination of aspirin and proton pump inhibitor
徐伟仙 1陈颖 2华尉利 2谢松梅 2王涛 2王水强2
作者信息
- 1. 北京大学 第三医院 心血管内科，北京100191
- 2. 国家食品药品监督管理总局 药品审评中心，北京 100038
- 折叠
摘要
Abstract
Low-dose aspirin (75-150 mg· d-1 ) is widely used in the management of ischemic cardiovascular and cerebrovascular diseases.As-pirin can cause gastrointestinal mucosal damage , ulceration and blee-ding.Proton pump inhibitor ( PPI) is a strong and long-last inhibitor of gastric acid secretion.In patients with long-term use of low-dose aspi-rin, PPI can be added for short time in the event of serious upper gastro-intestinal adverse reactions according to the clinical conditions.The ra-tionality of developing fixed -dose combination of aspirin and PPI is discussed in this paper.When the possible benefit/risk is taken into account , the basis for the developing fixed -dose combination of aspirin and PPI is insufficient.关键词
阿司匹林/质子泵抑制剂/固定剂量复方/获益/风险Key words
aspirin/proton pump inhibitor/fixed -dose combination/benefit/risk分类
药学引用本文复制引用
徐伟仙,陈颖,华尉利,谢松梅,王涛,王水强..阿司匹林和质子泵抑制剂固定复方制剂的立题合理性探讨[J].中国临床药理学杂志,2016,32(5):466-468,3.
