中国临床医学2016，Vol.23Issue(1)：17-21,5.
mTOR 通路下游核心分子的 mRNA表达水平与初发AML患者临床特征的关系
mRNA Expression of Core Molecules in the Downstream of mTOR Pathway and Its Relationship to Clinical ;Features in Primary Acute Myeloid Leukemia
摘要
Abstract
Objective:To explore the relationship between the mRNA expression of mammalian target of rapamycin (mTOR) , eukaryotic translation initiation factor 4E (eIF‐4E) and eukaryotic translation initiation factor 4E binding protein 1 (4E‐BP1) in bone marrow mononuclear cells of primary acute myeloid leukemia (AML) patients and clinical features of AML .Methods :The mRNA expression levels of 4E‐BP1 ,eIF‐4E and mTOR in bone marrow mononuclear cells were detected in 59 patients with primary AML and 15 normal human as a control group by reverse transcription‐polymerase chain reaction (RT‐PCR) . Results:The percentages of mTOR ,eIF‐4E and 4E‐BP1 mRNA high expression in 59 cases of AML were 50 .9% ,59 .4% and 45 .8% ,respectively .The platelet count in high 4E‐BP1 mRNA expression group was significantly lower than that in low group (P=0 .044) .The percentage of bone marrow blast cells in high eIF‐4E mRNA expression group was higher than that in low group ,but there was no significant difference between the two groups (P= 0 .068) .The percentage ,and extramedullary invasion of bone marrow blast cells in high mTOR expression group was significantly higher than that in low group (P=0 .040 , P=0 .029) .The percentage of anemia in high mTOR expression group was higher than that in low group ,but there was no significant difference between the two groups (P=0 .082) .Conclusions :Core protein mRNA in mTOR pathway downstream were closely relative to the proliferation of bone marrow blast cells ,PLT count ,anemia and extramedullary invasion in AML . They can help to choose effective and safe chemotherapy regimen ,as well as to prevent side effects of chemotherapy such as anemia and bleeding .关键词
急性白血病/哺乳动物雷帕霉素靶蛋白/临床特征Key words
Acute leukemia/Mammalian target of rapamycin/Clinical features分类
医药卫生引用本文复制引用
陈柯君,程辉,王健民,杨建民,吕书晴..mTOR 通路下游核心分子的 mRNA表达水平与初发AML患者临床特征的关系[J].中国临床医学,2016,23(1):17-21,5.基金项目
国家自然科学基金资助项目 （）
