中国临床医学2016，Vol.23Issue(1)：22-24,3.
高危遗传性心血管病患者致病基因表达的测定
Detection of the Pathogenic Gene Expression in Patients with High Risk Hereditary Cardiovascular Diseases
摘要
Abstract
Objective:To detect pathogenic gene expression in patients with high risk hereditary cardiovascular diseases and explore its predictive value for high risk ventricular arrhythmia .Methods :The expression of pathogenic genes in 30 patients with clinically diagnosed high risk hereditary cardiovascular diseases were detected by using second‐generation high‐throughput sequencing on the basis of gene chip probes associated with high risk hereditary cardiovascular diseases .The patients were divided into two groups by whether the malignant ventricular arrhythmia had happened . And gene expression features of pathogenic genes in the two groups were comparatively analyzed .Results: Among the 30 patients , there were 8 patients (positive rate 26 .67% ) with pathogenic genes .In ten cases with history of high risk ventricular arrhythmia ,the pathogenic gene positive rate was 20% (2/10) .And the pathogenic gene positive rate in control group was 30% (6/20) .The difference between the two groups was not statistically significant .Conclusions :There is a certain positive rate of pathogenic genes in patients with high risk hereditary cardiovascular diseases .However ,further researches are needed to confirm the predictive value of the pathogenic gene expression for high risk ventricular arrhythmia happened in these patients .关键词
高危遗传性心血管病/基因表达/心室颤动/室性心动过速/危险因素Key words
High risk hereditary cardiovascular diseases/Gene expression/Ventricular fibrillation/Ventricular tachycardia/Risk factor分类
医药卫生引用本文复制引用
赵昕,卜丽萍,彭娟,禹子清,徐化洁,樊冰,葛均波..高危遗传性心血管病患者致病基因表达的测定[J].中国临床医学,2016,23(1):22-24,3.基金项目
上海市科学技术委员会科研计划项目医学重点课题子课题 （）
