中国药理学通报2016，Vol.32Issue(3)：297-303,7.DOI:10.3969/j.issn.1001-1978.2016.03.001
炎症免疫反应软调节
Soft regulation of inflammatory immune responses
摘要
Abstract
Inflammation reaction and immune response are in-separable in the levels of system, tissue, cell and molecule. In-flammatory immune responses ( IIR) is proposed in this paper, which is defined a moderate or abnormal system responses of in-flammatory immune related cells in responding to the internal and external environment changes of body. It is described briefly that the research progresses of inflammatory immune cells ( e. g. , macrophages, dendritic cells, T cells and B cells, etc. ) and non-inflammatory immune cells ( e. g. , glial cells, endothe-lial cells, epithelial cells, fibroblasts, synovial cells and liver cells, etc. ) , and cytokines/receptor signal transduction in-volved in IIR. Moreover, the existing problems about regulating IIR drugs clinically are summarized. It is firstly put forward that soft regulation of inflammatory immune responses ( SRIIR) is a new direction of discovery and development of new drugs for the treatment of IIR related diseases.关键词
炎症免疫反应/炎症免疫反应软调节/免疫细胞/细胞因子/信号转导/新药发现Key words
inflammatory immune responses ( IIR)/soft regu-lation of inflammatory immune responses ( SRIIR )/immune cells/cytokines/signal transduction/discovery of new drugs分类
医药卫生引用本文复制引用
魏伟..炎症免疫反应软调节[J].中国药理学通报,2016,32(3):297-303,7.基金项目
国家自然科学基金重点项目资助(No 81330081) （No 81330081）
