中国药理学通报2016，Vol.32Issue(3)：304-309,6.DOI:10.3969/j.issn.1001-1978.2016.03.002
脑转移瘤动物模型的制备方法及研究进展
Animal models of brain metastasis：preparation methods and research progress
崔白苹 1陈平 2孙安阳1
作者信息
- 1. 盐城卫生职业技术学院神经退行性疾病与修复实验室
- 2. 盐城市第一人民医院肿瘤科，江苏 盐城 224005
- 折叠
摘要
Abstract
Brain metastasis ( BM) is a common brain tumor in a-dults, originating from extracranial location in the body. There has been a growing interest in producing suitable animal models for studying BM in vivo. Current BM models take peripheral or brain route for tumor cell inoculation, including intra-cardiac or intra-carotid artery injection or orthotopic injection. Direct im-plantation of patient tumor biopsies into rodent brain bears ad-vantages of clinical relevance. This review presents a compre-hensive introduction to key elements for establishing animal mod-els of BM, with highlights on selections of suitable model ani-mals, brain-seeking tumor cell lines, reasonable inoculation routes, as well as succedent phenotyping methods. In the end, perspectives and future directions in this field are discussed.关键词
脑转移/肿瘤/动物模型/裸鼠/细胞接种/制备方法/检测方法Key words
brain metastasis/tumor/animal models/nude mice/cell inoculation/model preparation/model evaluation分类
医药卫生引用本文复制引用
崔白苹,陈平,孙安阳..脑转移瘤动物模型的制备方法及研究进展[J].中国药理学通报,2016,32(3):304-309,6.
