中国药理学通报2016，Vol.32Issue(3)：310-313,314,5.DOI:10.3969/j.issn.1001-1978.2016.03.003
Wnt/β-catenin信号通路参与脑缺血后神经血管单元调控及相关药物的研究进展
Advances in studies on regulating effects of Wnt/β-catenin signaling pathway on neurovascular unit after cerebral Ischemia and related medicine
摘要
Abstract
Wnt signals widely exist in live creatures,involved in many physical or pathological processes,including the cell prolif-eration, differentiation and apoptosis. Recent studies show that Wnt/β-catenin signaling pathway may play an important regula-tory role in the protective effects of neurovascular unit in ische-mic stroke. Some chemicals,such as sulindac and estradiol,and some compound traditional Chinese medicine which contains gly-coside( e. g. rhodiola rosea ) , volatile oil ( e. g. turmeric ) and compound prescription ( e. g. Dan Long Xing Nao Fang ) can protect the neurovascular unit by regulating the pathway. This aims to review the research progress of the protective effects of Wnt/β-catenin signaling pathway on the neurovascular unit in is-chemic stroke,with combination of chemicals and traditional Chi-nese medicine which can protect the neurovascular unit via Wnt/β-catenin signaling pathway. It aims to provide the methodology basis for elucidating the mechanism of drugs,and also provide a new idea for researching the new drug which can reduce the dis-ability rate caused by sequela of stroke.关键词
Wnt/β-catenin信号通路/缺血性脑中风/神经血管单元/化学药/中药及复方/研究进展Key words
Wnt/β-catenin signaling pathway/ischemic stroke/neurovascular unit/chemical drugs/traditional Chinese medicine and compounds/research progress分类
医药卫生引用本文复制引用
文静,王建,罗世兰,彭婉,任奕米..Wnt/β-catenin信号通路参与脑缺血后神经血管单元调控及相关药物的研究进展[J].中国药理学通报,2016,32(3):310-313,314,5.基金项目
国家自然科学基金面上项目(No 81473371) （No 81473371）
