中国药理学通报2016，Vol.32Issue(3)：314-318,319,6.DOI:10.3969/j.issn.1001-1978.2016.03.004
法尼酯衍生物X受体在慢性肝病中的作用及机制研究进展
Progress on roles and mechanisms of farnesoid X receptor (FXR) in chronic liver diseases
摘要
Abstract
Farnesoid X receptor ( FXR) plays a key role in me-tabolism of substance, such as bile acid, lipid, glucose,( etc) . Newly published credible discoveries have claimed that as a reg-ulatory hub in metabolism, FXR is closely linked with diverse chronic liver diseases, including viral hepatitis, alcoholic fatty liver disease, nonalcoholic fatty liver disease, hepatic fibrosis and hepatocellular carcinoma. This review summarizes the roles and mechanisms of FXR during the courses of chronic liver dis-eases, aiming at providing novel insights and therapeutic target for antifibrotic research and drug development.关键词
FXR/病毒性肝炎/酒精性脂肪肝/非酒精性脂肪肝/肝纤维化/肝癌Key words
FXR/viral hepatitis/alcoholic fatty liver disease/non-alcoholic fatty liver disease/hepatic fibrosis/hepatocellular carcinoma分类
医药卫生引用本文复制引用
许文萱,张自力,赵士峰,张峰,吴丽,陆茵,郑仕中..法尼酯衍生物X受体在慢性肝病中的作用及机制研究进展[J].中国药理学通报,2016,32(3):314-318,319,6.基金项目
国家自然科学基金资助项目(No 81270514,31401210) （No 81270514,31401210）
江苏省自然科学基金青年基金( No BK20140955) （ No BK20140955）
江苏省高校自然科学研究面上项目(No 14KJB310011) （No 14KJB310011）
江苏高校优秀科技创新团队计划 （）
江苏高校优势学科建设工程资助项目(No ysxk-2010) （No ysxk-2010）
