中国药理学通报2016，Vol.32Issue(3)：394-398,5.DOI:10.3969/j.issn.1001-1978.2016.03.019
阿魏酸钠治疗糖皮质激素性骨质疏松的实验研究
Effect of Sodium ferulate on glucocorticoid-induced osteoporosis
摘要
Abstract
Aim To study the influence of Sodium fer-ulate ( SF) on bone metabolism in glucocorticoid–in-duced osteoporosis rats. Methods Thirty cases of fe-male Wistar Rats(3-month-old) were divided into con-trol group, model group and SF group ( low-dose group, middle-dose group, high-dose group ) by ran-domized block design. Double fluorochrome labeling with calcein was performed before necropsy. The left tibia was taken for bone histomorphometry. Results In static parameters, the proximal tibia cancellous bone trabecular thickness, trabecular quantity and area ratio were significantly reduced in model group compared with control group;while compared with model group, those were increased in middle and high-dose SF group. Trabecular separation degree was increased in model group compared with control group, while it was decreased in middle and high-dose SF group compared with model group. In dynamic parameters, the calcula-tion parameters of cancellous bone mark perimeter rate and the bone formation rate were increased in model group compared with control group, in middle and high-dose SF group the bone formation rate was in-creased compared with model group. In bone cells, os-teoclast number per mm, osteoblast number per mm, percent osteoblast surface perimeter and percent osteo-clast surface perimeter were increased in model group compared with control group. In growth-plate, the thickness of growth-plate was increased in model group compared with control group. In bone cells and growth-plate there was no statistical significance between treat-ment group and model group. Conclusion This study demonstrates that SF can increase bone mass and im-prove bone structure,which may be related to the im-provement of bone formation. SF is effective for GIOP in rats.关键词
糖皮质激素性骨质疏松/阿魏酸钠/骨组织形态计量学/骨组织细胞/生长板/骨小梁/松质骨Key words
GIOP/Sodium ferulate/bone histomor-phometry studies/bone cell/growth-plate/bone tra-becula/cancellous bone分类
医药卫生引用本文复制引用
刘洋,陆幸妍,陈珺,翟玉莹,叶小天,肖珊,柯诗韵,李青南,杨国柱,卢丽..阿魏酸钠治疗糖皮质激素性骨质疏松的实验研究[J].中国药理学通报,2016,32(3):394-398,5.基金项目
国家自然科学基金面上项目( No 30971172) （ No 30971172）
广东省科技 （）
