中国药理学通报2016，Vol.32Issue(3)：399-402,403,5.DOI:10.3969/j.issn.1001-1978.2016.03.020
鞣花酸体外抗真菌活性及对小鼠白色念珠菌感染模型的治疗作用研究
Therapeutic effect of ellagic acid on Candida albicans infect mice models and its antifungal activity in vitro
摘要
Abstract
Aim To investigate the inhibitory effect of ellagic acid( EA) on fungal strains both in vitro and in vivo. Methods The minimal inhibitory concentration ( MIC ) was determined by the NCCLS ( M27-A2 ) standard method in vitro. The therapeutic action was studied using a Candida albicans infect mice model, the survival rate and the content of SOD, MDA in ser-um were measured, and the pathological changes of liver were observed under light microscope after HE staining. Results EA was active against three Candida strains, with MICs between 25. 0 and 75. 0 mg·L-1 . The most sensitive Candida species was C. albicans ( MIC=25. 0 mg·L-1 ) . It was inactive against Can-dida glabrata. An in vivo test demonstrated that intrap-eritoneal injection of EA(40 and 80 mg·kg-1 ) signif-icantly enhanced the pathological changes of liver, im-proved the symptom, increased the weight and the SOD activity, and decreased the MDA activity in a mice in-fection model of C. albicans. Conclusion Ellagic acid has the potential to be developed as a natural antifungal agent.关键词
鞣花酸/抗真菌/最低抑菌浓度/白色念珠菌/小鼠/丙二醛/超氧化物歧化酶Key words
ellagic acid/antifungal activity/minimal inhibitory concentration/C. albicans/mice/MDA/SOD引用本文复制引用
阿米娜·阿不拉,斯拉甫艾白,古力娜达吾提,李治建..鞣花酸体外抗真菌活性及对小鼠白色念珠菌感染模型的治疗作用研究[J].中国药理学通报,2016,32(3):399-402,403,5.基金项目
新疆维吾尔自治区高技术研究发展计划项目(No 201517112) （No 201517112）
