中国药理学与毒理学杂志2016，Vol.30Issue(3)：248-257,10.DOI:10.3867/j.issn.1000-3002.2016.03.011
药物成瘾的表观遗传学机制研究进展
Progress in research of epigenetic mechanisms of drug addiction
摘要
Abstract
Drug addiction is a chronic relapsing brain disease that is characterized by compulsive drug use and persistence of drug craving. Drug abuse can lead to changes in the neuron structure and function of plasticity,alterations in molecules and cells,and ultimately to individual abnormal behavior. Current studies have found that epigenetic changes leading to the sustainability of gene expression is an important mechanism of drug addiction. In this review,we will systematically summarize the latest advances in epigenetic mechanisms of drug addiction. This review is expected to provide robust evidence that repeated exposure to drugs of abuse induces changes within the brain′s reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation , DNA methylation,and non-coding RNAs. It promises a new perspective from which to gain insights into the genetic and epigenetic mechanisms of drug addiction and a new area for epigenetic research on clinical drug addiction treatment.关键词
药物成瘾/表观遗传学/组蛋白修饰/DNA甲基化/非编码RNAKey words
drug addiction/epigenetics/histone modification/DNA methylation/noncoding RNA分类
医药卫生引用本文复制引用
徐文锦,陈为升,刘惠芬..药物成瘾的表观遗传学机制研究进展[J].中国药理学与毒理学杂志,2016,30(3):248-257,10.基金项目
浙江省自然科学基金面上项目（LY14H310002）；宁波市科技计划项目（2013C50033，2015C110026）；国家重点基础研究发展计划(2015CB553504)@@@@The project supported by Provincial Natural Science Foundation of Zhejiang Province （LY14H310002）；Science and Technology Program of Ningbo City（2013C50033，2015C110026）；and National Basic Research Program of China （2015CB553504）
