糖尿病肾病中转化生长因子β1/Sma和Mad相关蛋白信号通路的作用及其相关药物研究进展OA北大核心CSCDCSTPCD
Effect of transforming growth factor beta 1/Sma-and Mad-related protein signal pathway in diabetic nephropathy and related drugs:a review
转化生长因子β1（TGF-β1）参与糖尿病肾病（DN）的进程已作为临床慢性肾病进展的重要生物学标志物和治疗靶标。Sma和Mad相关蛋白（Smad）是TGF-β家族下游信号转导蛋白，TGF-β1与受体结合激活Smad2和Smad3，上调细胞核内结缔组织生长因子的转录，Smad3促进系膜细胞增生、细胞外基质积聚和细胞上皮间质转化，导致肾纤维化；Smad2和Smad7则起着负向调控作用，抑制肾纤维化。TGF-β1特异性抑制剂（SB431542等）具有抗…查看全部>>
Transforming growth factor-β1(TGF-β1)has become an important biological marker and therapeutic target of clinical progression of chronic kidney diseases. Sma- and Mad-related protein (Smad)is a downstream signal transduction protein of the TGF-β family. TGF-β1 activates Smad2 and Smad3 before increasing the transcription of connective tissue growth factors in the nucleus. Smad3 promotes mesangial cell proliferation,extracellular matrix accumulation,epithelia…查看全部>>
贾会玉;李中南;陈光亮
安徽中医药大学中西医结合临床学院，安徽合肥 230038安徽中医药大学第一附属医院，安徽合肥 230031安徽中医药大学中西医结合临床学院，安徽合肥 230038
医药卫生
糖尿病肾病转化生长因子β1信号通路药物
diabetic nephropathytransforming growth factor-β1signaling pathwaydrugs
《中国药理学与毒理学杂志》 2016 (3)
266-271,6
国家中医临床研究基地业务建设科研专项项目（JDZX2012004）@@@@The project supported by National Basic Research Project of TCM（JDZX2012004）
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