中国药理学与毒理学杂志2016，Vol.30Issue(3)：278-285,8.DOI:10.3867/j.issn.1000-3002.2016.03.015
人前列腺癌淋巴转移动物模型的研究进展
Animal models of human prostate cancer lymphatic metastasis:a review
摘要
Abstract
Prostate cancer is the most common cancer among males in the United states,and the incidence has risen dramatically in recent years in China. Lymph node metastasis is a strong predictor of the metastatic potential and poor outcome of prostate cancer. Animal models of human prostate cancer lymphatic metastasis can be used to study the pathogenesis and metastatic mechanisms of prostate cancer,and evaluate the efficacy of new drugs for lymphatic metastasis of prostate cancer. This paper reviews commonly-used animal models of human prostate cancer lymphatic metastasis,including xenograft mouse models,genetically engineered mouse models,rat models and canine models,analyzes their advantages and disadvantages,presents their functions and characteristics,introduces the applications of cancer stem cells in these models and test methods of these models,and highlights the main problems to be solved.关键词
前列腺癌/肿瘤转移/淋巴转移/动物模型/干细胞Key words
prostate cancer/neoplasm metastasis/lymphatic metastasis/animal models/stem cells分类
医药卫生引用本文复制引用
张树江,孙祖越..人前列腺癌淋巴转移动物模型的研究进展[J].中国药理学与毒理学杂志,2016,30(3):278-285,8.基金项目
上海市科委研发公共服务平台（13DZ2291300）；上海市实验动物创新行动计划（14140901302）@@@@The project supported by Science and Technolog Commission of Shanghai Research and Development Public Service Platform（13DZ2291300）；and Shanghai Laboratory Animal Innovation Action Plan （）
