摘要
Abstract
OBJECTIVE:To investigate the off-label drug use conditions in pediatric outpatient department of Jingzhou Maternal and Child Health Hospital ( hereinafter referred to as "our hospital") , and to provide reference for the ration drug use in children .METHODS:Prescriptions from pediatric outpatient department of our hospital in 2014 were randomly selected,to judge the medical orders by the drug instruction ,and statistical analysis was conducted on the incidence and types of off-label drug use ,incidence of off-label drug use in children at different age stages and the drugs categories , etc.RESULTS:Of the 1 200 sampled prescriptions , 3 258 cases involved in medical orders , the incidence rate of off-label drug use were 43.83%.The top 3 types of off-label drug use were respectively over optimal application groups ( 53.81%) , over times of administration ( 20.30%) , over dosage of administration ( 13.20%) . Infancy(45.26%),toddler age (45.15%)and preschool age (44.03%)dominated the top 3 places.Meanwhile,the top 3 drugs of off-label drug use were microbe and mineral drugs (55.87%),Chinese patent medicine (50.29%)and anti-infectious agents (46.40%) .CONCLUSIONS:Off-label drug use is a widely existing phenomena ,which needs the clinical physicians to have a good knowledge of drug introductions , and to carry out off-label drug use only with the permission of the patients 'parents;at the same time, the Health Administration should formulate the related management system on off-label drug use ,so as to ensure the safe and effective medication in children .关键词
超说明书用药/儿科门诊/安全、合理用药Key words
Off-label drug use/Pediatric outpatient department/Safe and effective medication分类
医药卫生
