中国中医药信息杂志2016，Vol.23Issue(3)：23-26,4.DOI:10.3969/j.issn.1005-5304.2016.03.007
中药外治法联合大桑菊合剂口服治疗儿童肺炎支原体肺炎临床研究
Clinical Study on Treating Mycoplasma Pneumoniae Pneumonia in Children by TCM External Treatment Combined with Dasangju Mixture
摘要
Abstract
Objective To investigate the clinical efficacy of TCM external treatment combined with Dasangju Mixture in treating mycoplasma pneumoniae pneumonia (MPP) in children. Methods One hundred patients with MPP were randomly divided into control group and treatment group by parallel design, with 50 patients in each group. Patients in control group orally took azithromycin combined with other symptomatic treatment when necessary, 7 d for a course and continuously for 3 courses. Based on the treatment for control group, patients in treatment group were added with TCM external treatment (BL13 and RN17) combined with Dasangju Mixture, while azithromycin was sequentially used just for 2 courses. Other types of treatment lasted for 3 courses. The improvement time of symptoms and signs of the patients were recorded and the therapeutic effects of the two groups were evaluated. Moreover, the serum concentrations of mycoplasma pneumoniae-immune gloulin M (MP-IgM) were determined before and after treatment on the 1st and 21st days. Results The improvent time of fever, and cough and lung sign of the treatment group were more obviously shortened than the control group (P<0.05). The total effective rate was 96.0% (48/50) in observation group and 74.0% (37/50) in control group, with statistical significant difference between the two groups (P<0.05). After treatment, the negative rate of the serum concentration of MP-IgM in the treatment group was 82%, and that of the control group was 58%, with statistical significance between the two groups (P<0.05).Conclusion TCM external treatment combined with Dasangju Mixture can not only significantly improve the clinical symptoms and signs of MPP children patients, but also shorten the disease course, and the efficacy was significant. Meanwhile it can reduce the course and side effects of azithromycin, which provides reference to the administration of antibiotics in children.关键词
中药外治法/大桑菊合剂/肺炎支原体肺炎Key words
TCM external treatment/Dasangju Mixture/mycoplasma pneumoniae pneumonia分类
医药卫生引用本文复制引用
余德钊,徐嘉辉,韦泓娟,蓝燕娇,李宏贵,林晓洁..中药外治法联合大桑菊合剂口服治疗儿童肺炎支原体肺炎临床研究[J].中国中医药信息杂志,2016,23(3):23-26,4.基金项目
广东省自然科学基金（2014A030313646）；广东省中医药局科技项目 （）
