中国中医药信息杂志2016，Vol.23Issue(4)：61-63,3.DOI:10.3969/j.issn.1005-5304.2016.04.016
太芪培元颗粒体外抗HIV-1病毒活性研究
Study on Vitro Anti-HIV-1 Activity ofTaiqi PeiyuanGranules
摘要
Abstract
ObjectiveTo evaluate the vitro anti-HIV-1 activity ofTaiqi Peiyuan Granules.MethodsMTT was used to detect cytotoxicity ofTaiqi Peiyuan Granules; cytopathy method was used to detect the inhibitory activity of Taiqi Peiyuan Granules on acute infection of HIV-1; HIV-1 p24 antigen ELISA detection was used to detect inhibitory activity ofTaiqi Peiyuan Granules for virus replication of HIV-1 acute infection cells, and count the medical therapeutic indexes.ResultsCC50ofTaiqi Peiyuan Granules in cytotoxicity test was 3.761±0.370 mg/mL; the EC50 of inhibition syncytial test was 0.454 5±0.204 6 mg/mL; the therapeutic index was between 5.84 and 12.97; p24 ofTaiqi Peiyuan Granules in inhibition experiments was 0.56±0.27 mg/mL, and the therapeutic index was between 5.30 and 8.74.ConclusionAnti-HIV-1 activity ofTaiqi Peiyuan Granules is relatively weak.关键词
太芪培元颗粒/人类免疫缺陷病毒/体外抗病毒活性/免疫机制Key words
Taiqi Peiyuan Granules/human immunodeficiency virus/vitro antiviral activity/immunologic mechanism分类
医药卫生引用本文复制引用
马秀兰,马建萍,张颖,艾合买提·阿不都热依木,李静茹,曾琳,郑永唐,杨柳萌,马丽雪..太芪培元颗粒体外抗HIV-1病毒活性研究[J].中国中医药信息杂志,2016,23(4):61-63,3.基金项目
国家科技重大专项（2014ZX10005003）；新疆医科大学科研创新基金项目 （）
