中国中医药信息杂志2016，Vol.23Issue(4)：87-90,4.DOI:10.3969/j.issn.1005-5304.2016.04.023
星点设计-效应面法优化亚麻木酚素缓释片处方
Optimization of Prescription of Flaxseed Lignans Sustained-release Tablets by Central Composite Design-response Surface Methodology
摘要
Abstract
Objective To optimize the prescription of flaxseed lignans sustained release tables by central composite design-response surface methodology.MethodsWith HPMC, EC and starch dosage as factors, and flaxseed lignans in 2, 6 and 12 h of cumulative release as evaluation indexes, central composite design-response surface optimization method was used to conduct prescription optimization experiments, and optimized prescription analysis was carried out.Results The optimal prescription of flaxseed lignans sustained release tables was as following: HPMC dosage was 43%; EC was 26%; starch content was 17%. Optimized index forecast values were very close to the observed values. In vitro release test of three selected optimal formulations indicated that there existed high approximation between the observed and estimated values.Conclusion It shows that the established model is suitable for flaxseed lignans sustained release tables, which can be used in the optimization of the prescription of flaxseed lignans sustained release tables.关键词
亚麻木酚素/缓释片/星点设计-效应面法Key words
flaxseed lignans/sustained-release tablets/central composite design-response surface methodology分类
医药卫生引用本文复制引用
刘效栓,李季文,吴晓琴,舒劲,焦正花,钱梦茹,毕映燕..星点设计-效应面法优化亚麻木酚素缓释片处方[J].中国中医药信息杂志,2016,23(4):87-90,4.基金项目
甘肃省科技支撑计划 （）
