北京中医药大学学报2016，Vol.39Issue(3)：204-207,4.DOI:10.3969/j.issn.1006-2157.2016.03.007
芍药内酯苷、芍药苷对血虚免疫抑制小鼠的补血作用及机制
Blood-enriching effects and mechanism of albiflorin and paeoniflorin on immunosuppressional model mice with blood deficiency pattern
摘要
Abstract
Objective To observe the blood-enriching effects and mechanism of albiflorin and paeoniflorin on immunosuppressional model mice with blood deficiency pattern induced by cyclophospha-mide.Methods The mouse model with blood deficiency pattern induced by intraperitoneal injection of cyclophosphamide was treated with intragastrical administration of albiflorin and paeoniflorin at high dose of 30 mg/kg,low dose of 15 mg/kg.Then the peripheral hemogram,thymus gland index and spleen index,granulocyte-macrophage colony stimulating factor (GM-CSF),interleukin-3 (IL-3),interleukin-6 (IL-6),tumor necrosis factor α(TNF-α)and granulocyte colony-stimulating factor were detected. Results High dose albiflorin and high dose paeoniflorin could increase WBC count(P <0.01 )and thymus gland index (P <0.01,P <0.05),serum contents of GM-CSF and G-CSF (P <0.001,P <0.01),also serum content of IL-3 (P <0.01,P <0.05),and decrease the serum content of IL-6(P <0.05)and TNF-α(P <0.001,P <0.01 ).Conclusion The blood-enriching effects against blood-deficiency via regulating the immunological function,suggests that albiflorin and paeoniflorin be the main effective components extracted from White Peony Root (Radix Paeoniae Alba,Baishao)with the effects of nourishing blood and liver.关键词
芍药内酯苷/芍药苷/血虚证/细胞造血因子/小鼠Key words
albiflorin/paeoniflorin/blood deficiency pattern/cytokines/mice分类
医药卫生引用本文复制引用
朱映黎,王林元,赵丹萍,王成龙,吴丽,张建军..芍药内酯苷、芍药苷对血虚免疫抑制小鼠的补血作用及机制[J].北京中医药大学学报,2016,39(3):204-207,4.基金项目
国家自然科学基金项目 （）
