北京中医药大学学报2016，Vol.39Issue(3)：230-234,5.DOI:10.3969/j.issn.1006-2157.2016.03.011
姜黄素对小鼠海马 Aβ生成酶和降解酶的影响
Effects of curcumin on β-amyloid generating enzyme and degrading en-zymes in hippocampus in mice
摘要
Abstract
decreased significantly in the model group (P <0.01);compared with the model group,expressions of IDE and NEP increased significantly in all the intervention groups with IDE and NEP-positive cells in hippocampus CA1 region increasing(P <0.01 or P <0.05).Conclusion It is suggested that one of potential mechanisms of curcumin reducing Aβaccumulation may be via increasing Aβ-degrading enzyme IDE and NEP expression and reducing Aβ-generating enzyme PS2 expression.关键词
姜黄素/阿尔茨海默病/早老素 2/胰岛素降解酶/脑啡肽酶/小鼠Key words
curcumin/Alzheimer’s disease/presenilin 2/insulin degrading enzyme/neprilysin/mice分类
医药卫生引用本文复制引用
董云芳,冯慧利,何瑛琨,樊惠,党惠子,任映,王蓬文..姜黄素对小鼠海马 Aβ生成酶和降解酶的影响[J].北京中医药大学学报,2016,39(3):230-234,5.基金项目
国家自然科学基金面上资助项目（No．81073076），教育部高等学校创新团队 （）
