重庆医学2016，Vol.45Issue(7)：896-898,3.DOI:10.3969/j.issn.1671-8348.2016.07.010
正常皮质醇垂体腺瘤围术期不常规激素替代治疗探讨
Discussion on no routine glucocorticoids replacement of pituitary adenoma with normal cortisol in perioperative period
摘要
Abstract
Objective To evaluate the security of no routine glucocorticoids replacement of pituitary adenoma with normal cortisol in perioperative period .Methods We retrospectively analyzed 66 cases of pituitary tumor resection operation with normal serum cortisol that did not receive perioperative routine glucocorticoids .Changes of cortisol and ACT H levels in the morning 8 :00 preoperative and postoperative day 1 ,3 ,and 7 were observed and compared .Statistics on the perioperative complications was also collected .Results The levels of cortisol and ACTH on postoperative day 1 were higher than preoperative and the differences were statistically significant(P<0 .01) .The levels of cortisol and ACT H on postoperative day 3 and 7 recovered to preoperative level , but without statistical significances(P>0 .05) .Three patients failed to achieve normal postoperative cortisol level and only 1 pa‐tients complicated with hyponatremia ,but none of them appeared clinical presentation associated with low cortisol such as poor mental .Conclusion The postoperative cortisol of pituitary adenoma with normal preoperative cortisol can meet the needs of periop‐erative itself .On the premise that the level of cortisol and clinical manifestations associated with low cortisol are closely monitored , it is safe that pituitary adenoma with normal cortisol doesn′t use glucocorticoids routinely .关键词
垂体腺瘤/围术期/肾上腺皮质功能低下/皮质醇/替代治疗Key words
pituitary adenoma/perioperative period/adrenocortical insufficiency/cortisol/replacement therapy分类
医药卫生引用本文复制引用
张彪,阿库布千,钟传洪,陈礼刚,夏祥国..正常皮质醇垂体腺瘤围术期不常规激素替代治疗探讨[J].重庆医学,2016,45(7):896-898,3.基金项目
泸州医学院附属医院科研课题计划青年基金资助项目（2015-67）。 （）
