重庆医学2016，Vol.45Issue(8)：1049-1052,4.DOI:10.3969/j.issn.1671-8348.2016.08.014
胃癌组织中NRP-1的表达与临床病理特征及预后的相关性
Expression of NRP-1 in gastric cancer tissue and its correlation with clinicopathological characteristics and prognosis
摘要
Abstract
Objective To detect the expression of NRP‐1 in gastric cancer tissue ,to analyze its relationship with clinicopath‐ological features ,and to explore its value in judging the prognosis of gastric cancer .Methods The clinical pathologic data and prog‐nosis situation in 168 cases of gastric cancer were retrospectively analyzed .The expression of NRP‐1 in gastric cancer tissue and normal tissue was detected by the immunohistochemical method .The relationship between the expression of NRP‐1 with the clinico‐pathological features and prognosis was investigated .Whether NRP‐1 serving as a reference indicator for judging the prognosis of gastric cancer was evaluated .Results (1) In 168 cases ,the NRP‐1 expression in gastric cancer tissue was higher than that in nor‐mal tissue (66 .7% vs .8 .33% ,P<0 .05) .(2) The NRP‐1 expression was related with the tumor size ,differentiation degree ,infil‐trative depth ,lymph node metastasis and TNM stage(P<0 .05) .(3)The median survival time in the patients with high NRP‐1 ex‐pression was shorter than that in the patients with low NRP‐1 expression (P<0 .05) .(4) The multiple factor analysis by COX pro‐portional hazard model showed that the NRP‐1 expression was an independent risk factor for the prognosis of gastric cancer(P<0 .05) .Conclusion (1)NRP‐1 plays an important role in the incidence and development process of gastric cancer and its expression is closely related with the malignant biological behavior of gastric cancer .(2)The high NRP‐1 expression prompts poor prognosis .(3) NRP‐1 may be expected to be regarded as one of the indexes for judging the biologic behaviors and prognosis of gastric cancer .关键词
胃肿瘤/预后/神经纤毛蛋白-1Key words
gastric neoplasms/prognosis/neuropilin-1分类
医药卫生引用本文复制引用
徐卫国,杨少君,王宇鹏,刘云,张世伟,徐洪,贾纯亮,孙红,刘和亮..胃癌组织中NRP-1的表达与临床病理特征及预后的相关性[J].重庆医学,2016,45(8):1049-1052,4.基金项目
河北省科学技术研究与发展计划（10276115D）。 （）
