重庆医学2016，Vol.45Issue(9)：1195-1197,3.DOI:10.3969/j.issn.1671-8348.2016.09.014
维生素D对老年2型糖尿病患者胰岛素抵抗影响的研究
Study on effects of vitamin D supplementation on insulin resistance in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the effects of oral vitamin D supplementation on insulin resistance(IR)in the patients with type 2 diabetes mellitus(T2DM ) .Methods A total of 16 elderly patients with T2DM in our hospital were included as the research subjects and divided into the observation and control groups according to the random number method .The two groups received the conventional hypoglycemic therapy .The observation group was simultaneously added with calcitriol (0 .50μg/d for 12 weeks) .The blood sugar related indicators and serum 25-(OH)D3 level were detected by collecting fasting venous blood before and after treat-ment measured .Results BMI ,FBG ,HbA1c ,Fins ,25-(OH)D3 and IRI after treatment in the two groups were improved signifi-cantly with statistically significant difference (P<0 .05) ,moreover BMI ,FBG ,HbA1c ,Fins ,25-(OH)D3 and IRI after treatment in the observation group were improved more significantly compared with the control group ,and the differences were statistically sig-nificant (P<0 .05) .The patients with 25-(OH)D3 level < 25 nmol/L had significant improvement in BMI ,FBG ,HbA1c ,Fins and 25-(OH)D3 level ,the differences were statistically significant (P<0 .05) .There was positive correlation between 25-(OH)D3 with BMI ,FBG ,HbA1c ,Fins and IRI (P<0 .05) .Conclusion The vitamin D supplementation can better improve the IR status on the basis of conventional hypoglycemic therapy and promotes the blood glucose stability in the elderly patients with T2DM .关键词
糖尿病 ,2型/维生素D/老年人/胰岛素抵抗Key words
diabetes mellitus ,type 2/vitamin D/aged/insulin resistance分类
医药卫生引用本文复制引用
汪晓红,李莉..维生素D对老年2型糖尿病患者胰岛素抵抗影响的研究[J].重庆医学,2016,45(9):1195-1197,3.基金项目
2015年度武汉市卫生局临床医学科研项目（WX15D31）。 （）
